Dihydrodictyopyrones A and C: new members of dictyopyrone family isolated from Dictyostelium cellular slime molds

Haruhisa Kikuchi; Koji Nakamura; Yuzuru Kubohara; Naomi Gokan; Kohei Hosaka; Yasuo Maeda; Yoshiteru Oshima

doi:10.1016/j.tetlet.2007.06.040

Dihydrodictyopyrones A and C: new members of dictyopyrone family isolated from Dictyostelium cellular slime molds

Haruhisa Kikuchi, Koji Nakamura, Yuzuru Kubohara, Naomi Gokan, Kohei Hosaka, Yasuo Maeda, Yoshiteru Oshima

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We have explored the diversity of secondary metabolites produced by cellular slime molds to evaluate if they are valuable resources for biologically potential substances. From the methanol extract of fruiting bodies of Dicyostelium firmibasis, we obtained new α-pyranoids, dihydrodictyopyrones A (1) and C (2). Their structures including absolute configurations were determined by spectral means and asymmetric total synthesis. Compounds 1 and 2 are new members of the dictyopyrone family, which are characteristic secondary metabolites of various species of Dictyostelium cellular slime molds.

Original language	English
Pages (from-to)	5905-5909
Number of pages	5
Journal	Tetrahedron Letters
Volume	48
Issue number	33
DOIs	https://doi.org/10.1016/j.tetlet.2007.06.040
Publication status	Published - 2007 Aug 13
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2007.06.040

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title = "Dihydrodictyopyrones A and C: new members of dictyopyrone family isolated from Dictyostelium cellular slime molds",

abstract = "We have explored the diversity of secondary metabolites produced by cellular slime molds to evaluate if they are valuable resources for biologically potential substances. From the methanol extract of fruiting bodies of Dicyostelium firmibasis, we obtained new α-pyranoids, dihydrodictyopyrones A (1) and C (2). Their structures including absolute configurations were determined by spectral means and asymmetric total synthesis. Compounds 1 and 2 are new members of the dictyopyrone family, which are characteristic secondary metabolites of various species of Dictyostelium cellular slime molds.",

author = "Haruhisa Kikuchi and Koji Nakamura and Yuzuru Kubohara and Naomi Gokan and Kohei Hosaka and Yasuo Maeda and Yoshiteru Oshima",

note = "Funding Information: This work was supported in part by Chugai Pharmaceutical Co., Ltd and a Grant-in-Aid for Scientific Research (No. 18710179) from the Ministry of Education, Science, Sports, and Culture of Japan.",

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AU - Kikuchi, Haruhisa

AU - Nakamura, Koji

AU - Kubohara, Yuzuru

AU - Gokan, Naomi

AU - Hosaka, Kohei

AU - Maeda, Yasuo

AU - Oshima, Yoshiteru

N1 - Funding Information: This work was supported in part by Chugai Pharmaceutical Co., Ltd and a Grant-in-Aid for Scientific Research (No. 18710179) from the Ministry of Education, Science, Sports, and Culture of Japan.

PY - 2007/8/13

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N2 - We have explored the diversity of secondary metabolites produced by cellular slime molds to evaluate if they are valuable resources for biologically potential substances. From the methanol extract of fruiting bodies of Dicyostelium firmibasis, we obtained new α-pyranoids, dihydrodictyopyrones A (1) and C (2). Their structures including absolute configurations were determined by spectral means and asymmetric total synthesis. Compounds 1 and 2 are new members of the dictyopyrone family, which are characteristic secondary metabolites of various species of Dictyostelium cellular slime molds.

AB - We have explored the diversity of secondary metabolites produced by cellular slime molds to evaluate if they are valuable resources for biologically potential substances. From the methanol extract of fruiting bodies of Dicyostelium firmibasis, we obtained new α-pyranoids, dihydrodictyopyrones A (1) and C (2). Their structures including absolute configurations were determined by spectral means and asymmetric total synthesis. Compounds 1 and 2 are new members of the dictyopyrone family, which are characteristic secondary metabolites of various species of Dictyostelium cellular slime molds.

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Dihydrodictyopyrones A and C: new members of dictyopyrone family isolated from Dictyostelium cellular slime molds

Abstract

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