Direct asymmetric α-allylation of ketones with allylic alcohols Via Pd/enamine cooperative function

Shigeo Yasuda, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Direct asymmetric α-allylation of ketones with allylic alcohols is described. The combination of palladium with a new phosphine ligand bearing a chiral proline moiety promoted the reaction to afford the corresponding α-allylated ketones in moderate yield and enantioselectivity.

Original languageEnglish
Pages (from-to)745-757
Number of pages13
JournalHeterocycles
Volume86
Issue number1
DOIs
Publication statusPublished - 2012
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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