Direct attachment of microbial organisms to material surfaces through sequence-specific DNA hybridization

Amy A. Twite, Sonny C. Hsiao, Hiroaki Onoe, Richard A. Mathies, Matthew B. Francis

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

A new technique is reported for the attachment of synthetic DNA strands to the surfaces of microbial organisms. This gives algal, bacterial, and fungal cells the ability to bind to complementary strands extending from patterned surfaces that can be produced on platforms such as microfluidic devices. The ability of this method to establish complex 2- and 3-dimensional cocultures comprising multiple organism types is also presented.

Original languageEnglish
Pages (from-to)2380-2385
Number of pages6
JournalAdvanced Materials
Volume24
Issue number18
DOIs
Publication statusPublished - 2012 May 8
Externally publishedYes

Keywords

  • DNA
  • microbial cells
  • nitrogen fixation
  • photosynthetic organisms
  • surface patterning

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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