Direct biliopancreatoduodenal invasion by hepatocellular carcinoma

Report of the first resected case and review of the literature

Yutaro Kato, Kentaro Matsubara, Yoshinobu Akiyama, Hiroaki Hattori, Akira Hirata, Tatsuya Yamamoto, Fumio Suzuki, Hitoshi Ohtaka, Yoshiaki Sugiura, Masaki Kitajima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A rare resected case of hepatocellular carcinoma (HCC) invading the duodenum, the common bile duct (CBD), the gallbladder, and the pancreas is described. A 63-year-old man presented with a painful upper abdominal mass. Radiologic findings showed a 25-cm liver tumor arising from segment IV with an invasive extension to the hepatoduodenal ligament and pancreatoduodenal region, with a single intrahepatic metastasis. The patient successfully underwent a left hepatectomy in conjunction with a pylorus-preserving pancreatoduodenectomy (PD). As an unusual procedure, liver parenchymal transection was followed by PD to explore tumor resectability, because the overhanging liver mass precluded full hepatoduodenal ligament dissection. He was discharged without surgical complications, being free from antianalgesics, which had been used preoperatively. The main tumor was histologically diagnosed to be a poorly differentiated HCC with sarcomatous change invading the duodenum, the CBD, the gallbladder, and the pancreas. Unfortunately, aggressive hepatic and nodal recurrence, which was resistant to salvage chemotherapy, caused the patient's death at 8 months postoperatively. This is the first documented case of HCC with biliopancreatoduodenal invasion resected by hepatopancreatoduodenectomy. Literature review suggests a significant role of resection in selected patients with HCC with contiguous gastrointestinal tract invasion, particularly when the HCCs are naive without any forms of previous treatment. However, further surgical and nonsurgical experience is necessary to determine the oncological validity of aggressive surgery for HCC invading the biliopancreatoduodenal region.

Original languageEnglish
Pages (from-to)421-427
Number of pages7
JournalInternational Journal of Clinical Oncology
Volume16
Issue number4
DOIs
Publication statusPublished - 2011 Aug
Externally publishedYes

Fingerprint

Hepatocellular Carcinoma
Pancreaticoduodenectomy
Liver
Common Bile Duct
Gallbladder
Duodenum
Ligaments
Pancreas
Neoplasms
Pylorus
Hepatectomy
Gastrointestinal Tract
Dissection
Neoplasm Metastasis
Recurrence
Drug Therapy
Therapeutics

Keywords

  • Bile duct
  • Duodenum
  • Hepatocellular carcinoma
  • Hepatopancreatoduodenectomy
  • Invasion
  • Pancreas
  • Sarcomatous

ASJC Scopus subject areas

  • Oncology
  • Surgery
  • Hematology

Cite this

Direct biliopancreatoduodenal invasion by hepatocellular carcinoma : Report of the first resected case and review of the literature. / Kato, Yutaro; Matsubara, Kentaro; Akiyama, Yoshinobu; Hattori, Hiroaki; Hirata, Akira; Yamamoto, Tatsuya; Suzuki, Fumio; Ohtaka, Hitoshi; Sugiura, Yoshiaki; Kitajima, Masaki.

In: International Journal of Clinical Oncology, Vol. 16, No. 4, 08.2011, p. 421-427.

Research output: Contribution to journalArticle

Kato, Yutaro ; Matsubara, Kentaro ; Akiyama, Yoshinobu ; Hattori, Hiroaki ; Hirata, Akira ; Yamamoto, Tatsuya ; Suzuki, Fumio ; Ohtaka, Hitoshi ; Sugiura, Yoshiaki ; Kitajima, Masaki. / Direct biliopancreatoduodenal invasion by hepatocellular carcinoma : Report of the first resected case and review of the literature. In: International Journal of Clinical Oncology. 2011 ; Vol. 16, No. 4. pp. 421-427.
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