Direct catalytic asymmetric alkynylation of ketoimines

Liang Yin, Yasunari Otsuka, Hisashi Takada, Shinsuke Mouri, Ryo Yazaki, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

An efficient protocol for direct catalytic alkynylation of ketoimines is described. The simultaneous activation of a soft Lewis basic terminal alkyne and a ketoimine bearing a thiophosphinoyl group by soft Lewis acid Cu(I) is crucial for high conversion. The reaction can be rendered asymmetric with a chiral bisphosphine ligand (S,S)-Ph-BPE.

Original languageEnglish
Pages (from-to)698-701
Number of pages4
JournalOrganic Letters
Volume15
Issue number3
DOIs
Publication statusPublished - 2013 Feb 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Direct catalytic asymmetric alkynylation of ketoimines'. Together they form a unique fingerprint.

Cite this