Abstract
An efficient protocol for direct catalytic alkynylation of ketoimines is described. The simultaneous activation of a soft Lewis basic terminal alkyne and a ketoimine bearing a thiophosphinoyl group by soft Lewis acid Cu(I) is crucial for high conversion. The reaction can be rendered asymmetric with a chiral bisphosphine ligand (S,S)-Ph-BPE.
Original language | English |
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Pages (from-to) | 698-701 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 15 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2013 Feb 1 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry