Abstract
An α-CF 3 amide underwent direct asymmetric Mannich-type reaction to isatin imines in the presence of a chiral catalyst comprising a soft Lewis acid Cu(I), a chiral bisphosphine ligand, and Barton's base. The Mannich adduct was converted in one step into a unique tricycle bearing a trifluoromethylated chiral center and an α-tertiary amine moiety.
Original language | English |
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Pages (from-to) | 488-492 |
Number of pages | 5 |
Journal | Synlett |
Volume | 30 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2019 |
Externally published | Yes |
Keywords
- asymmetric catalysis
- copper catalysis
- fluorine
- heterocycle
- Mannich reaction
ASJC Scopus subject areas
- Organic Chemistry