Taking the reins: The title transformation of thioamides and N-diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard Brønsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme). Divergent transformation of the thioamide functionality highlights the utility of this methodology.
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2009 Jun 22|
- Asymmetric catalysis
- Mannich reactions
- Proton transfer
ASJC Scopus subject areas