Direct chemoselective allylation of inert amide carbonyls

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Direct allylation of inert amide carbonyls utilizing the Schwartz reagent afforded either substituted tertiary or secondary amines. A preactivation step was successfully avoided, which is generally a requisite to increase the electrophilicity of amides. The reaction exhibited remarkable functional group tolerance and proceeded even in the presence of methyl esters and nitro groups.

Original languageEnglish
Pages (from-to)950-953
Number of pages4
JournalOrganic Letters
Volume14
Issue number3
DOIs
Publication statusPublished - 2012 Feb 3

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Allylation
Amides
amides
Functional groups
Amines
reagents
esters
amines
Esters

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Direct chemoselective allylation of inert amide carbonyls. / Oda, Yukiko; Satou, Takaaki; Chida, Noritaka.

In: Organic Letters, Vol. 14, No. 3, 03.02.2012, p. 950-953.

Research output: Contribution to journalArticle

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