Direct chemoselective allylation of inert amide carbonyls

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Abstract

Direct allylation of inert amide carbonyls utilizing the Schwartz reagent afforded either substituted tertiary or secondary amines. A preactivation step was successfully avoided, which is generally a requisite to increase the electrophilicity of amides. The reaction exhibited remarkable functional group tolerance and proceeded even in the presence of methyl esters and nitro groups.

Original languageEnglish
Pages (from-to)950-953
Number of pages4
JournalOrganic Letters
Volume14
Issue number3
DOIs
Publication statusPublished - 2012 Feb 3

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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