Direct demonstration of immunoregulatory T-cell defects in patients with systemic lupus erythematosus

J. Koide, M. Takano, Tsutomu Takeuchi, O. Hosono, K. Amano, M. Homma, T. Abe

Research output: Contribution to journalArticle

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Abstract

The present study was undertaken to determine directly whether immunoregulatory T cells have a defective suppressor function in patients with systemic lupus erythematosus (SLE), and whether anti-T-cell antibodies are essential for immunoregulatory T-cell defects. Peripheral blood T cells and T-cell subsets were determined in 52 SLE patients. The ratio of T4 to T8 cells was distributed over a wider range in patients with SLE than in the controls. Patients with SLE were divided into three groups (low, normal and high) by the T4/T8 ratio. Lymphocytes from 12 SLE patients (7 with low and 5 with high T4/T8 ratios) were studied extensively. Their disease was inactive or in remission. Anti-T-cell antibodies were not detected, and yet the patients had immunological abnormalities characterized by the presence of antinuclear antibodies and hypergammaglobulinaemia. The SLE patients with high T4/T8 ratios had a decreased number of T8 cells, and defective suppressor-effector cells. In contrast, patients with low T4/T8 ratios had decreased T4 cells and/or increased T8 cells, and defective suppressor-inducer cells. Two patients with low T4/T8 ratios had both suppressor-effector and suppressor-inducer cell defects. These results indicate that immunoregulatory circuits in SLE patients are heterogeneous and that immunoregulatory defects exist even when the disease is inactive or in remission. Anti-T-cell antibodies were not essential for such immunoregulatory defects. Thus, immunoregulatory T-cell defects and the development of SLE may be independent conditions due to other unknown causes.

Original languageEnglish
Pages (from-to)449-459
Number of pages11
JournalScandinavian Journal of Immunology
Volume23
Issue number4
Publication statusPublished - 1986

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Systemic Lupus Erythematosus
T-Lymphocytes
CD4-CD8 Ratio
CD8-Positive T-Lymphocytes
Helper-Inducer T-Lymphocytes
Antibodies
CD4-Positive T-Lymphocytes
Hypergammaglobulinemia
Antinuclear Antibodies
T-Lymphocyte Subsets
Blood Cells
Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Direct demonstration of immunoregulatory T-cell defects in patients with systemic lupus erythematosus. / Koide, J.; Takano, M.; Takeuchi, Tsutomu; Hosono, O.; Amano, K.; Homma, M.; Abe, T.

In: Scandinavian Journal of Immunology, Vol. 23, No. 4, 1986, p. 449-459.

Research output: Contribution to journalArticle

Koide, J, Takano, M, Takeuchi, T, Hosono, O, Amano, K, Homma, M & Abe, T 1986, 'Direct demonstration of immunoregulatory T-cell defects in patients with systemic lupus erythematosus', Scandinavian Journal of Immunology, vol. 23, no. 4, pp. 449-459.
Koide, J. ; Takano, M. ; Takeuchi, Tsutomu ; Hosono, O. ; Amano, K. ; Homma, M. ; Abe, T. / Direct demonstration of immunoregulatory T-cell defects in patients with systemic lupus erythematosus. In: Scandinavian Journal of Immunology. 1986 ; Vol. 23, No. 4. pp. 449-459.
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