Direct proline catalyzed asymmetric α-aminooxylation of aldehydes

Yujiro Hayashi, Junichiro Yamaguchi, Kazuhiro Hibino, Mitsuru Shoji

Research output: Contribution to journalArticle

287 Citations (Scopus)

Abstract

The direct catalytic enantioselective α-aminooxylation of aldehydes has been developed using nitrosobenzene as the oxygen source and L-proline as catalyst, affording versatile α-aminooxylated aldehydes in high yield with excellent enantioselectivities.

Original languageEnglish
Pages (from-to)8293-8296
Number of pages4
JournalTetrahedron Letters
Volume44
Issue number45
DOIs
Publication statusPublished - 2003 Nov 3
Externally publishedYes

Fingerprint

Proline
Aldehydes
Enantioselectivity
Oxygen
Catalysts
nitrosobenzene

Keywords

  • α-aminooxylation
  • Asymmetric reaction
  • Catalytic reaction
  • Organocatalyst
  • Proline

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Direct proline catalyzed asymmetric α-aminooxylation of aldehydes. / Hayashi, Yujiro; Yamaguchi, Junichiro; Hibino, Kazuhiro; Shoji, Mitsuru.

In: Tetrahedron Letters, Vol. 44, No. 45, 03.11.2003, p. 8293-8296.

Research output: Contribution to journalArticle

Hayashi, Y, Yamaguchi, J, Hibino, K & Shoji, M 2003, 'Direct proline catalyzed asymmetric α-aminooxylation of aldehydes', Tetrahedron Letters, vol. 44, no. 45, pp. 8293-8296. https://doi.org/10.1016/j.tetlet.2003.09.057
Hayashi, Yujiro ; Yamaguchi, Junichiro ; Hibino, Kazuhiro ; Shoji, Mitsuru. / Direct proline catalyzed asymmetric α-aminooxylation of aldehydes. In: Tetrahedron Letters. 2003 ; Vol. 44, No. 45. pp. 8293-8296.
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