Direct reprogramming of mouse fibroblasts into cardiac myocytes

Kohei Inagawa, Masaki Ieda

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The potency of specific transcription factors as cell fate determinants was first demonstrated by the discovery of MyoD, a master gene for skeletal muscle transdifferentiation. More recently, the induction of pluripotency in somatic cells using a combination of stem cell-specific transcription factors has been reported. That elegant study altered the approach to regenerative medicine and inspired new strategies for generating specific cell types by introducing combinations of lineage-specific transcription factors. A diverse range of cell types, such as pancreatic β-cells, neurons, chondrocytes, and hepatocytes, can be induced from heterologous cells using lineage-specific reprogramming factors. Furthermore, functional cardiomyocytes can be generated directly from differentiated somatic cells using several combinations of cardiac-enriched defined factors in the mouse. The present article reviews the pioneering and recent studies in cellular reprogramming and discusses the perspectives and challenges of direct cardiac reprogramming in regenerative therapy.

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalJournal of Cardiovascular Translational Research
Volume6
Issue number1
DOIs
Publication statusPublished - 2013 Feb

Fingerprint

Cardiac Myocytes
Fibroblasts
Transcription Factors
Regenerative Medicine
Cell Lineage
Chondrocytes
Hepatocytes
Skeletal Muscle
Stem Cells
Neurons
Genes

Keywords

  • Cardiac regeneration
  • Direct reprogramming
  • Heart
  • Induced cardiomyocytes
  • Stem cell

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics
  • Genetics(clinical)
  • Molecular Medicine
  • Pharmaceutical Science

Cite this

Direct reprogramming of mouse fibroblasts into cardiac myocytes. / Inagawa, Kohei; Ieda, Masaki.

In: Journal of Cardiovascular Translational Research, Vol. 6, No. 1, 02.2013, p. 37-45.

Research output: Contribution to journalArticle

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