Direct synthesis of hydroxyapatite-silk fibroin nano-composite sol via a mechanochemical route

Rei Nemoto, Satoshi Nakamura, Tetsuhiko Isobe, Mamoru Senna

Research output: Contribution to journalArticle

46 Citations (Scopus)


In the presence of fine silk cocoon (silk fibroin, SF) powder, a low viscosity sol of nano-hydroxyapatite (HAp, Ca10(PO4)6(OH)2)-SF was synthesized by a wet mechanochemical reaction. Nano crystals of HAp are oriented along their c-axis. The secondary structure of SF was changed by milling. A uniform thin gel film was obtained by a simple dip coating on the glass substrate precoated by chitosan.

Original languageEnglish
Pages (from-to)7-12
Number of pages6
JournalJournal of Sol-Gel Science and Technology
Issue number1-2
Publication statusPublished - 2001 Jun 1



  • Hydroxyapatite-silk fibroin
  • Mechanochemical reaction
  • Nano-composite sol

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Biomaterials
  • Condensed Matter Physics
  • Materials Chemistry

Cite this