Disappearance of serum hepatitis C virus RNA within two days after one dose interferon administration is predictive for response to high-dose interferon-α2b treatment for chronic hepatitis C

Hidetsugu Saito, Hirotoshi Ebinuma, Kazuhiro Atsukawa, Masahiko Takahashi, Tetsuya Masuda, Tazuko Ohishi, Osamu Nojiri, Keiji Mizuoka, Hiromasa Ishii

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We have reported the Keio multicenter randomized trial of interferon- α2b treatment fur chronic hepatitis C, hypothesizing that disappearance of serum hepatitis C virus (HCV) ribonucleic acid (RNA) during the first 2 days by one dose administration of interferon is a predictive factor of final response to the high-dose interferon treatment. In this study we quantified HCV RNA by multicyclic reverse transcription-polymerase chain reaction in the stored sera of the same patients with our previous study. The multivariate analysis confirmed that the pretreatment HCV RNA levels and HCV genotype were significantly correlated with the response to the 6-month course interferon treatment. Although the relationship between decreased HCV RNA titers within the first 2 days after one dose administration of interferon and the efficacy of the therapy was nut obtained, the cases in which HCV RNA disappeared within 2 days significantly responded to the 6-month course treatment (73.7% vs 12.5% in other cases, p< 0.01). The present study has confirmed the hypothesis suggested in the previous study that clearance of HCV RNA during the first 2 days has a predictive value for the final outcome.

Original languageEnglish
Pages (from-to)74-80
Number of pages7
JournalKeio Journal of Medicine
Volume46
Issue number2
DOIs
Publication statusPublished - 1997 Jun

Keywords

  • Chronic hepatitis C
  • Efficacy of the therapy
  • HCV RNA
  • Interferon
  • Quantitation

ASJC Scopus subject areas

  • Medicine(all)

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