Disappearance of steroid hormone dependency during malignant transformation of ovarian clear cell cancer

Tomoko Akahane, Akihiko Sekizawa, Tsuyoshi Okuda, Miki Kushima, Hiroshi Saito, Takashi Okai

Research output: Contribution to journalArticle

14 Citations (Scopus)


Ovarian clear-cell carcinoma (OCCA) and ovarian endometrioid carcinoma (OEMC) are often associated with endometriosis. This study determined the immunohistochemical expression of steroid hormone receptors and cancer-related genes in OCCA and OEMC specimens containing endometriosis and atypical endometriosis. Pathological progression from endometriosis to atypical endometriosis to carcinoma was identified in 4 of 22 OCCAs and 4 of 16 OEMCs. Using paraffin-embedded tissue samples, expression and changes in expression for estrogen receptors (ERs) and progesterone receptors (PRs) were examined in relation to the observed pathological changes. A gradual reduction in ERa and PRA expression was observed with malignant transformation from endometriosis to atypical endometriosis to OCCA. In OEMC, ERα expression increased with malignant transformation. In conclusion, reductions in ERα and PRA expression were observed with progression from endometriosis to atypical endometriosis in OCCA specimens. Disappearance of hormone dependency might therefore be associated with malignant transformation to OCCA.

Original languageEnglish
Pages (from-to)369-376
Number of pages8
JournalInternational Journal of Gynecological Pathology
Issue number4
Publication statusPublished - 2005 Oct 1



  • Atypical endometriosis
  • Endometriosis
  • Ovarian clear cell carcinoma
  • Ovarian endometrioid carcinoma
  • Progesterone receptor
  • Receptor
  • c-erbb-2
  • p53

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology

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