TY - JOUR
T1 - Disappearance of steroid hormone dependency during malignant transformation of ovarian clear cell cancer
AU - Akahane, Tomoko
AU - Sekizawa, Akihiko
AU - Okuda, Tsuyoshi
AU - Kushima, Miki
AU - Saito, Hiroshi
AU - Okai, Takashi
PY - 2005/10/1
Y1 - 2005/10/1
N2 - Ovarian clear-cell carcinoma (OCCA) and ovarian endometrioid carcinoma (OEMC) are often associated with endometriosis. This study determined the immunohistochemical expression of steroid hormone receptors and cancer-related genes in OCCA and OEMC specimens containing endometriosis and atypical endometriosis. Pathological progression from endometriosis to atypical endometriosis to carcinoma was identified in 4 of 22 OCCAs and 4 of 16 OEMCs. Using paraffin-embedded tissue samples, expression and changes in expression for estrogen receptors (ERs) and progesterone receptors (PRs) were examined in relation to the observed pathological changes. A gradual reduction in ERa and PRA expression was observed with malignant transformation from endometriosis to atypical endometriosis to OCCA. In OEMC, ERα expression increased with malignant transformation. In conclusion, reductions in ERα and PRA expression were observed with progression from endometriosis to atypical endometriosis in OCCA specimens. Disappearance of hormone dependency might therefore be associated with malignant transformation to OCCA.
AB - Ovarian clear-cell carcinoma (OCCA) and ovarian endometrioid carcinoma (OEMC) are often associated with endometriosis. This study determined the immunohistochemical expression of steroid hormone receptors and cancer-related genes in OCCA and OEMC specimens containing endometriosis and atypical endometriosis. Pathological progression from endometriosis to atypical endometriosis to carcinoma was identified in 4 of 22 OCCAs and 4 of 16 OEMCs. Using paraffin-embedded tissue samples, expression and changes in expression for estrogen receptors (ERs) and progesterone receptors (PRs) were examined in relation to the observed pathological changes. A gradual reduction in ERa and PRA expression was observed with malignant transformation from endometriosis to atypical endometriosis to OCCA. In OEMC, ERα expression increased with malignant transformation. In conclusion, reductions in ERα and PRA expression were observed with progression from endometriosis to atypical endometriosis in OCCA specimens. Disappearance of hormone dependency might therefore be associated with malignant transformation to OCCA.
KW - Atypical endometriosis
KW - Endometriosis
KW - Ovarian clear cell carcinoma
KW - Ovarian endometrioid carcinoma
KW - Progesterone receptor
KW - Receptor
KW - c-erbb-2
KW - p53
UR - http://www.scopus.com/inward/record.url?scp=25444520748&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=25444520748&partnerID=8YFLogxK
U2 - 10.1097/01.pgp.0000165173.90339.a2
DO - 10.1097/01.pgp.0000165173.90339.a2
M3 - Article
C2 - 16175084
AN - SCOPUS:25444520748
VL - 24
SP - 369
EP - 376
JO - International Journal of Gynecological Pathology
JF - International Journal of Gynecological Pathology
SN - 0277-1691
IS - 4
ER -