Discontinuation of living donor liver transplantation for PSC due to histological abnormalities in intraoperative donor liver biopsy

Y. Hasegawa, S. Kawachi, M. Shimazu, K. Hoshino, M. Tanabe, Y. Fuchimoto, H. Obara, M. Shinoda, H. Shimizu, Y. Yamada, T. Akatsu, R. Irie, M. Sakamoto, Y. Morikawa, M. Kitajima

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11 Citations (Scopus)

Abstract

Liver transplantation is the only curative treatment known to date for end-stage liver disease occurring as a result of primary sclerosing cholangitis (PSC). Here, we report a case in which living donor liver transplantation (LDLT) for PSC was cancelled because of histological abnormalities in intraoperative biopsy of the donor liver. The donor was the mother of the recipient, and her preoperative evaluation revealed no abnormalities. In the donor operation, the donor liver biopsy revealed expansion of the portal zone with lymphocytic infiltration and dense concentric fibrosis developed around a bile duct. These histological findings were identical to those of early-stage PSC; therefore, the LDLT was called off. The experience in this case suggests that preoperative liver biopsy may be useful to exclude first-degree relative donors with potential PSC prior to LDLT for PSC.

Original languageEnglish
Pages (from-to)2204-2207
Number of pages4
JournalAmerican Journal of Transplantation
Volume7
Issue number9
DOIs
Publication statusPublished - 2007 Sep

Keywords

  • Donor operation
  • First degree relative donor
  • Liver biopsy
  • Living donor liver transplantation
  • PSC

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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