Discovery of biomarkers for osteosarcoma by proteomics approaches

Yoshiyuki Suehara, Daisuke Kubota, Kazutaka Kikuta, Kazuo Kaneko, Akira Kawai, Tadashi Kondo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Osteosarcomas are the most common malignant bone tumors, and the identification of useful tumor biomarkers and target proteins is required to predict the clinical outcome of patients and therapeutic response as well as to develop novel therapeutic strategies. Global protein expression studies, namely, proteomic studies, can offer important clues to understanding the tumor biology that cannot be obtained by other approaches. These studies, such as two-dimensional gel electrophoresis and mass spectrometry, have provided protein expression profiles of osteosarcoma that can be used to develop novel diagnostic and therapeutic biomarkers, as well as to understand biology of tumor progression and malignancy. In this paper, a brief description of the methodology will be provided followed by a few examples of the recent proteomic studies that have generated new information regarding osteosarcomas.

Original languageEnglish
Article number425636
JournalSarcoma
Volume2012
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Osteosarcoma
Proteomics
Biomarkers
Neoplasms
Proteins
Electrophoresis, Gel, Two-Dimensional
Tumor Biomarkers
Mass Spectrometry
Therapeutics
Bone and Bones

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Suehara, Y., Kubota, D., Kikuta, K., Kaneko, K., Kawai, A., & Kondo, T. (2012). Discovery of biomarkers for osteosarcoma by proteomics approaches. Sarcoma, 2012, [425636]. https://doi.org/10.1155/2012/425636

Discovery of biomarkers for osteosarcoma by proteomics approaches. / Suehara, Yoshiyuki; Kubota, Daisuke; Kikuta, Kazutaka; Kaneko, Kazuo; Kawai, Akira; Kondo, Tadashi.

In: Sarcoma, Vol. 2012, 425636, 2012.

Research output: Contribution to journalArticle

Suehara, Y, Kubota, D, Kikuta, K, Kaneko, K, Kawai, A & Kondo, T 2012, 'Discovery of biomarkers for osteosarcoma by proteomics approaches', Sarcoma, vol. 2012, 425636. https://doi.org/10.1155/2012/425636
Suehara Y, Kubota D, Kikuta K, Kaneko K, Kawai A, Kondo T. Discovery of biomarkers for osteosarcoma by proteomics approaches. Sarcoma. 2012;2012. 425636. https://doi.org/10.1155/2012/425636
Suehara, Yoshiyuki ; Kubota, Daisuke ; Kikuta, Kazutaka ; Kaneko, Kazuo ; Kawai, Akira ; Kondo, Tadashi. / Discovery of biomarkers for osteosarcoma by proteomics approaches. In: Sarcoma. 2012 ; Vol. 2012.
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