Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages

Rika Obata; Taichi Ohshiro; Hiroshi Tomoda; Shigeru Nishiyama

doi:10.1016/j.bmcl.2005.06.070

Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages

Rika Obata, Taichi Ohshiro, Hiroshi Tomoda, Shigeru Nishiyama

Department of Humanities and Social Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Halogenated cyclic isodityrosine-tripeptides were synthesized as analogues of a marine natural product, eurypamide B. Although the original eurypamides showed no inhibitory activity, the new analogues were found to inhibit lipid droplet accumulation in macrophages with a low micromolar IC₅₀ value.

Original language	English
Pages (from-to)	4189-4191
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	19
DOIs	https://doi.org/10.1016/j.bmcl.2005.06.070
Publication status	Published - 2005 Oct 1

Keywords

Antiatherosclerotic agents
Cyclic isodityrosine
Eurypamide
Lipid droplet accumulation inhibitor
Thallium(III) oxidation

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2005.06.070

Cite this

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title = "Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages",

abstract = "Halogenated cyclic isodityrosine-tripeptides were synthesized as analogues of a marine natural product, eurypamide B. Although the original eurypamides showed no inhibitory activity, the new analogues were found to inhibit lipid droplet accumulation in macrophages with a low micromolar IC50 value.",

keywords = "Antiatherosclerotic agents, Cyclic isodityrosine, Eurypamide, Lipid droplet accumulation inhibitor, Thallium(III) oxidation",

author = "Rika Obata and Taichi Ohshiro and Hiroshi Tomoda and Shigeru Nishiyama",

year = "2005",

month = oct,

day = "1",

doi = "10.1016/j.bmcl.2005.06.070",

language = "English",

volume = "15",

pages = "4189--4191",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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number = "19",

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TY - JOUR

T1 - Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages

AU - Obata, Rika

AU - Ohshiro, Taichi

AU - Tomoda, Hiroshi

AU - Nishiyama, Shigeru

PY - 2005/10/1

Y1 - 2005/10/1

N2 - Halogenated cyclic isodityrosine-tripeptides were synthesized as analogues of a marine natural product, eurypamide B. Although the original eurypamides showed no inhibitory activity, the new analogues were found to inhibit lipid droplet accumulation in macrophages with a low micromolar IC50 value.

AB - Halogenated cyclic isodityrosine-tripeptides were synthesized as analogues of a marine natural product, eurypamide B. Although the original eurypamides showed no inhibitory activity, the new analogues were found to inhibit lipid droplet accumulation in macrophages with a low micromolar IC50 value.

KW - Antiatherosclerotic agents

KW - Cyclic isodityrosine

KW - Eurypamide

KW - Lipid droplet accumulation inhibitor

KW - Thallium(III) oxidation

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U2 - 10.1016/j.bmcl.2005.06.070

DO - 10.1016/j.bmcl.2005.06.070

M3 - Article

C2 - 16054812

AN - SCOPUS:23944450117

SN - 0960-894X

VL - 15

SP - 4189

EP - 4191

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 19

ER -

Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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