Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages

Rika Obata, Taichi Ohshiro, Hiroshi Tomoda, Shigeru Nishiyama

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Halogenated cyclic isodityrosine-tripeptides were synthesized as analogues of a marine natural product, eurypamide B. Although the original eurypamides showed no inhibitory activity, the new analogues were found to inhibit lipid droplet accumulation in macrophages with a low micromolar IC50 value.

Original languageEnglish
Pages (from-to)4189-4191
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number19
DOIs
Publication statusPublished - 2005 Oct 1

Fingerprint

Macrophages
Biological Products
Inhibitory Concentration 50
Lipids
isodityrosine
Lipid Droplets

Keywords

  • Antiatherosclerotic agents
  • Cyclic isodityrosine
  • Eurypamide
  • Lipid droplet accumulation inhibitor
  • Thallium(III) oxidation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages. / Obata, Rika; Ohshiro, Taichi; Tomoda, Hiroshi; Nishiyama, Shigeru.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 19, 01.10.2005, p. 4189-4191.

Research output: Contribution to journalArticle

Obata, Rika ; Ohshiro, Taichi ; Tomoda, Hiroshi ; Nishiyama, Shigeru. / Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages. In: Bioorganic and Medicinal Chemistry Letters. 2005 ; Vol. 15, No. 19. pp. 4189-4191.
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