Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages

Rika Obata, Taichi Ohshiro, Hiroshi Tomoda, Shigeru Nishiyama

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Halogenated cyclic isodityrosine-tripeptides were synthesized as analogues of a marine natural product, eurypamide B. Although the original eurypamides showed no inhibitory activity, the new analogues were found to inhibit lipid droplet accumulation in macrophages with a low micromolar IC50 value.

Original languageEnglish
Pages (from-to)4189-4191
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number19
DOIs
Publication statusPublished - 2005 Oct 1

Keywords

  • Antiatherosclerotic agents
  • Cyclic isodityrosine
  • Eurypamide
  • Lipid droplet accumulation inhibitor
  • Thallium(III) oxidation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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