Discrimination between normal and malignant human gastric tissues by Fourier transform infrared spectroscopy

Naoko Fujioka; Yuji Morimoto; Tsunenori Arai; Makoto Kikuchi

doi:10.1016/j.cdp.2003.11.004

Discrimination between normal and malignant human gastric tissues by Fourier transform infrared spectroscopy

Naoko Fujioka, Yuji Morimoto, Tsunenori Arai, Makoto Kikuchi

Department of Applied Physics and Physico-Informatics

Research output: Contribution to journal › Article › peer-review

122 Citations (Scopus)

Abstract

The aim of this study was to determine whether malignant and normal human gastric tissues can be distinguished by Fourier transform infrared (FTIR) spectroscopy. Compared with normal tissue, malignant tissues showed significant increases in infrared (IR) absorption in 10 bands lying in a region of 925-1660cm^-1. Using the 10 IR absorption bands as markers, discriminant analysis was carried out for tissue discrimination. As a result, 22 out of the 23 gastric cancer samples and 9 out of the 12 gastric normal samples were correctly segregated, yielding 88.6% accuracy. The present results suggest that FTIR spectroscopy is a useful tool for screening gastric cancer.

Original language	English
Pages (from-to)	32-36
Number of pages	5
Journal	Cancer Detection and Prevention
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.cdp.2003.11.004
Publication status	Published - 2004

Keywords

Cancer diagnosis
Discriminant analysis
Gastric cancer

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1016/j.cdp.2003.11.004

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title = "Discrimination between normal and malignant human gastric tissues by Fourier transform infrared spectroscopy",

abstract = "The aim of this study was to determine whether malignant and normal human gastric tissues can be distinguished by Fourier transform infrared (FTIR) spectroscopy. Compared with normal tissue, malignant tissues showed significant increases in infrared (IR) absorption in 10 bands lying in a region of 925-1660cm-1. Using the 10 IR absorption bands as markers, discriminant analysis was carried out for tissue discrimination. As a result, 22 out of the 23 gastric cancer samples and 9 out of the 12 gastric normal samples were correctly segregated, yielding 88.6% accuracy. The present results suggest that FTIR spectroscopy is a useful tool for screening gastric cancer.",

keywords = "Cancer diagnosis, Discriminant analysis, Gastric cancer",

author = "Naoko Fujioka and Yuji Morimoto and Tsunenori Arai and Makoto Kikuchi",

note = "Funding Information: The authors are grateful to the staff of the Department of Surgery II, National Defense Medical College for supplying the gastric cancer samples. This work was supported by grants from the New Energy and Industrial Technology Development Organization (Tokyo, Japan). ",

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doi = "10.1016/j.cdp.2003.11.004",

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T1 - Discrimination between normal and malignant human gastric tissues by Fourier transform infrared spectroscopy

AU - Fujioka, Naoko

AU - Morimoto, Yuji

AU - Arai, Tsunenori

AU - Kikuchi, Makoto

N1 - Funding Information: The authors are grateful to the staff of the Department of Surgery II, National Defense Medical College for supplying the gastric cancer samples. This work was supported by grants from the New Energy and Industrial Technology Development Organization (Tokyo, Japan).

PY - 2004

Y1 - 2004

N2 - The aim of this study was to determine whether malignant and normal human gastric tissues can be distinguished by Fourier transform infrared (FTIR) spectroscopy. Compared with normal tissue, malignant tissues showed significant increases in infrared (IR) absorption in 10 bands lying in a region of 925-1660cm-1. Using the 10 IR absorption bands as markers, discriminant analysis was carried out for tissue discrimination. As a result, 22 out of the 23 gastric cancer samples and 9 out of the 12 gastric normal samples were correctly segregated, yielding 88.6% accuracy. The present results suggest that FTIR spectroscopy is a useful tool for screening gastric cancer.

AB - The aim of this study was to determine whether malignant and normal human gastric tissues can be distinguished by Fourier transform infrared (FTIR) spectroscopy. Compared with normal tissue, malignant tissues showed significant increases in infrared (IR) absorption in 10 bands lying in a region of 925-1660cm-1. Using the 10 IR absorption bands as markers, discriminant analysis was carried out for tissue discrimination. As a result, 22 out of the 23 gastric cancer samples and 9 out of the 12 gastric normal samples were correctly segregated, yielding 88.6% accuracy. The present results suggest that FTIR spectroscopy is a useful tool for screening gastric cancer.

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KW - Discriminant analysis

KW - Gastric cancer

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Discrimination between normal and malignant human gastric tissues by Fourier transform infrared spectroscopy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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