Discrimination between normal and malignant human gastric tissues by Fourier transform infrared spectroscopy

Naoko Fujioka, Yuji Morimoto, Tsunenori Arai, Makoto Kikuchi

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

The aim of this study was to determine whether malignant and normal human gastric tissues can be distinguished by Fourier transform infrared (FTIR) spectroscopy. Compared with normal tissue, malignant tissues showed significant increases in infrared (IR) absorption in 10 bands lying in a region of 925-1660cm-1. Using the 10 IR absorption bands as markers, discriminant analysis was carried out for tissue discrimination. As a result, 22 out of the 23 gastric cancer samples and 9 out of the 12 gastric normal samples were correctly segregated, yielding 88.6% accuracy. The present results suggest that FTIR spectroscopy is a useful tool for screening gastric cancer.

Original languageEnglish
Pages (from-to)32-36
Number of pages5
JournalCancer Detection and Prevention
Volume28
Issue number1
DOIs
Publication statusPublished - 2004 Jan 1

Keywords

  • Cancer diagnosis
  • Discriminant analysis
  • Gastric cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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