Abstract
The aim of this study was to determine whether malignant and normal human gastric tissues can be distinguished by Fourier transform infrared (FTIR) spectroscopy. Compared with normal tissue, malignant tissues showed significant increases in infrared (IR) absorption in 10 bands lying in a region of 925-1660cm-1. Using the 10 IR absorption bands as markers, discriminant analysis was carried out for tissue discrimination. As a result, 22 out of the 23 gastric cancer samples and 9 out of the 12 gastric normal samples were correctly segregated, yielding 88.6% accuracy. The present results suggest that FTIR spectroscopy is a useful tool for screening gastric cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 32-36 |
| Number of pages | 5 |
| Journal | Cancer Detection and Prevention |
| Volume | 28 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2004 |
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Keywords
- Cancer diagnosis
- Discriminant analysis
- Gastric cancer
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Discrimination between normal and malignant human gastric tissues by Fourier transform infrared spectroscopy. / Fujioka, Naoko; Morimoto, Yuji; Arai, Tsunenori; Kikuchi, Makoto.
In: Cancer Detection and Prevention, Vol. 28, No. 1, 2004, p. 32-36.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Discrimination between normal and malignant human gastric tissues by Fourier transform infrared spectroscopy
AU - Fujioka, Naoko
AU - Morimoto, Yuji
AU - Arai, Tsunenori
AU - Kikuchi, Makoto
PY - 2004
Y1 - 2004
N2 - The aim of this study was to determine whether malignant and normal human gastric tissues can be distinguished by Fourier transform infrared (FTIR) spectroscopy. Compared with normal tissue, malignant tissues showed significant increases in infrared (IR) absorption in 10 bands lying in a region of 925-1660cm-1. Using the 10 IR absorption bands as markers, discriminant analysis was carried out for tissue discrimination. As a result, 22 out of the 23 gastric cancer samples and 9 out of the 12 gastric normal samples were correctly segregated, yielding 88.6% accuracy. The present results suggest that FTIR spectroscopy is a useful tool for screening gastric cancer.
AB - The aim of this study was to determine whether malignant and normal human gastric tissues can be distinguished by Fourier transform infrared (FTIR) spectroscopy. Compared with normal tissue, malignant tissues showed significant increases in infrared (IR) absorption in 10 bands lying in a region of 925-1660cm-1. Using the 10 IR absorption bands as markers, discriminant analysis was carried out for tissue discrimination. As a result, 22 out of the 23 gastric cancer samples and 9 out of the 12 gastric normal samples were correctly segregated, yielding 88.6% accuracy. The present results suggest that FTIR spectroscopy is a useful tool for screening gastric cancer.
KW - Cancer diagnosis
KW - Discriminant analysis
KW - Gastric cancer
UR - http://www.scopus.com/inward/record.url?scp=3142707256&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3142707256&partnerID=8YFLogxK
U2 - 10.1016/j.cdp.2003.11.004
DO - 10.1016/j.cdp.2003.11.004
M3 - Article
VL - 28
SP - 32
EP - 36
JO - Cancer Epidemiology
JF - Cancer Epidemiology
SN - 1877-7821
IS - 1
ER -