Disrupted tRNA gene diversity and possible evolutionary scenarios

Junichi Sugahara, Kosuke Fujishima, Keisuke Morita, Masaru Tomita, Akio Kanai

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The following unusual tRNAs have recently been discovered in the genomes of Archaea and primitive Eukaryota: multiple-intron-containing tRNAs, which have more than one intron; split tRNAs, which are produced from two pieces of RNA transcribed from separate genes; tri-split tRNAs, which are produced from three separate genes; and permuted tRNA, in which the 5′ and 3′ halves are encoded with permuted orientations within a single gene. All these disrupted tRNA genes can form mature contiguous tRNA, which is aminoacylated after processing by cis or trans splicing. The discovery of such tRNA disruptions has raised the question of when and why these complex tRNA processing pathways emerged during the evolution of life. Many previous reports have noted that tRNA genes contain a single intron in the anticodon loop region, a feature common throughout all three domains of life, suggesting an ancient trait of the last universal common ancestor. In this context, these unique tRNA disruptions recently found only in Archaea and primitive Eukaryota provide new insight into the origin and evolution of tRNA genes, encouraging further research in this field. In this paper, we summarize the phylogeny, structure, and processing machinery of all known types of disrupted tRNAs and discuss possible evolutionary scenarios for these tRNA genes.

Original languageEnglish
Pages (from-to)497-504
Number of pages8
JournalJournal of Molecular Evolution
Volume69
Issue number5
DOIs
Publication statusPublished - 2009 Nov

Fingerprint

Transfer RNA
gene
Genes
genes
introns
Archaea
trans-splicing
Introns
common ancestry
Eukaryota
machinery
RNA
ancestry
phylogeny
genome
Trans-Splicing
Anticodon
Phylogeny

Keywords

  • Archaea
  • Cyanidioschyzon merolae
  • Evolution
  • Intron-containing tRNA
  • Permuted tRNA
  • Split tRNA
  • TRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Ecology, Evolution, Behavior and Systematics

Cite this

Disrupted tRNA gene diversity and possible evolutionary scenarios. / Sugahara, Junichi; Fujishima, Kosuke; Morita, Keisuke; Tomita, Masaru; Kanai, Akio.

In: Journal of Molecular Evolution, Vol. 69, No. 5, 11.2009, p. 497-504.

Research output: Contribution to journalArticle

Sugahara, Junichi ; Fujishima, Kosuke ; Morita, Keisuke ; Tomita, Masaru ; Kanai, Akio. / Disrupted tRNA gene diversity and possible evolutionary scenarios. In: Journal of Molecular Evolution. 2009 ; Vol. 69, No. 5. pp. 497-504.
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