Dissecting the formation, structure and barrier function of the stratum corneum

Takeshi Matsui, Masayuki Amagai

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The skin is the largest organ of the mammalian body. The outermost layer of mammalian skin, the stratum corneum (SC) of the epidermis, consists of piles of dead corneocytes that are the endproducts of terminal differentiation of epidermal keratinocytes. The SC performs a crucial barrier function of epidermis. Langerhans cells, when activated, extend their dendrites through tight junctions just beneath the SC to capture external antigens. Recently, knowledge of the biology of corneocytes ('corneobiology') has progressed rapidly and many key factors that modulate its barrier function have been identified and characterized. In this review article on the SC, we summarize its evolution, formation, structure and function. Cornification is an important step of SC formation at the conversion of living epithelial cells to dead corneocytes, and consists of three major steps: formation of the intracellular keratin network, cornified envelopes and intercellular lipids. After cornification, the SC undergoes chemical reactions to form the mature SC with different functional layers. Finally, the SC is shed off at the surface ('desquamation'), mediated by a cascade of several proteases. This review will be helpful to understand our expanding knowledge of the biology of the SC, where immunity meets external antigens.

Original languageEnglish
Pages (from-to)269-280
Number of pages12
JournalInternational Immunology
Volume27
Issue number6
DOIs
Publication statusPublished - 2015 Jun 1

Fingerprint

Cornea
Epidermis
Antigens
Skin
Langerhans Cells
Tight Junctions
Keratins
Dendrites
Keratinocytes
Immunity
Peptide Hydrolases
Epithelial Cells
Lipids

Keywords

  • Barrier
  • Epidermis
  • Evolution
  • Langerhans
  • Skin
  • Stratum corneum

ASJC Scopus subject areas

  • Immunology

Cite this

Dissecting the formation, structure and barrier function of the stratum corneum. / Matsui, Takeshi; Amagai, Masayuki.

In: International Immunology, Vol. 27, No. 6, 01.06.2015, p. 269-280.

Research output: Contribution to journalArticle

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