Dissolution profile of 24 levofloxacin (100 mg) tablets

Kayoko Maezawa; Ryo Yajima; Tomoko Terajima; Junko Kizu; Seiji Hori

doi:10.1007/s10156-012-0530-4

Dissolution profile of 24 levofloxacin (100 mg) tablets

Kayoko Maezawa, Ryo Yajima, Tomoko Terajima, Junko Kizu, Seiji Hori

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.

Original language	English
Pages (from-to)	996-998
Number of pages	3
Journal	Journal of Infection and Chemotherapy
Volume	19
Issue number	5
DOIs	https://doi.org/10.1007/s10156-012-0530-4
Publication status	Published - 2013 Oct

Keywords

Brand name
Dissolution
Generic
Levofloxacin
Tablet

ASJC Scopus subject areas

Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

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title = "Dissolution profile of 24 levofloxacin (100 mg) tablets",

abstract = "Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.",

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note = "Funding Information: Conflict of interest S.H. has received consultation fees from Daiichi Sankyo Co., Ltd. (Tokyo, Japan) and Meiji Seika Pharma Co., Ltd. (Tokyo, Japan), and financial support from Daiichi Sankyo Co., Ltd. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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AU - Terajima, Tomoko

AU - Kizu, Junko

AU - Hori, Seiji

N1 - Funding Information: Conflict of interest S.H. has received consultation fees from Daiichi Sankyo Co., Ltd. (Tokyo, Japan) and Meiji Seika Pharma Co., Ltd. (Tokyo, Japan), and financial support from Daiichi Sankyo Co., Ltd. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2013/10

Y1 - 2013/10

N2 - Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.

AB - Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.

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Dissolution profile of 24 levofloxacin (100 mg) tablets

Abstract

Keywords

ASJC Scopus subject areas

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