Abstract
Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.
| Original language | English |
|---|---|
| Pages (from-to) | 996-998 |
| Number of pages | 3 |
| Journal | Journal of Infection and Chemotherapy |
| Volume | 19 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2013 Oct |
Keywords
- Brand name
- Dissolution
- Generic
- Levofloxacin
- Tablet
ASJC Scopus subject areas
- Microbiology (medical)
- Pharmacology (medical)
- Infectious Diseases
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Cite this
Maezawa, K., Yajima, R., Terajima, T., Kizu, J., & Hori, S. (2013). Dissolution profile of 24 levofloxacin (100 mg) tablets. Journal of Infection and Chemotherapy, 19(5), 996-998. https://doi.org/10.1007/s10156-012-0530-4