Abstract
Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.
| Original language | English |
|---|---|
| Pages (from-to) | 996-998 |
| Number of pages | 3 |
| Journal | Journal of Infection and Chemotherapy |
| Volume | 19 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2013 Oct |
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Keywords
- Brand name
- Dissolution
- Generic
- Levofloxacin
- Tablet
ASJC Scopus subject areas
- Microbiology (medical)
- Pharmacology (medical)
- Infectious Diseases
Cite this
Dissolution profile of 24 levofloxacin (100 mg) tablets. / Maezawa, Kayoko; Yajima, Ryo; Terajima, Tomoko; Kizu, Junko; Hori, Seiji.
In: Journal of Infection and Chemotherapy, Vol. 19, No. 5, 10.2013, p. 996-998.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dissolution profile of 24 levofloxacin (100 mg) tablets
AU - Maezawa, Kayoko
AU - Yajima, Ryo
AU - Terajima, Tomoko
AU - Kizu, Junko
AU - Hori, Seiji
PY - 2013/10
Y1 - 2013/10
N2 - Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.
AB - Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.
KW - Brand name
KW - Dissolution
KW - Generic
KW - Levofloxacin
KW - Tablet
UR - http://www.scopus.com/inward/record.url?scp=84885957045&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885957045&partnerID=8YFLogxK
U2 - 10.1007/s10156-012-0530-4
DO - 10.1007/s10156-012-0530-4
M3 - Article
C2 - 23380968
AN - SCOPUS:84885957045
VL - 19
SP - 996
EP - 998
JO - Journal of Infection and Chemotherapy
JF - Journal of Infection and Chemotherapy
SN - 1341-321X
IS - 5
ER -