Dissolution profile of 24 levofloxacin (100 mg) tablets

Kayoko Maezawa, Ryo Yajima, Tomoko Terajima, Junko Kizu, Seiji Hori

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.

Original languageEnglish
Pages (from-to)996-998
Number of pages3
JournalJournal of Infection and Chemotherapy
Volume19
Issue number5
DOIs
Publication statusPublished - 2013 Oct

Fingerprint

Levofloxacin
Tablets
Names
Japan
Pharmacokinetics

Keywords

  • Brand name
  • Dissolution
  • Generic
  • Levofloxacin
  • Tablet

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Dissolution profile of 24 levofloxacin (100 mg) tablets. / Maezawa, Kayoko; Yajima, Ryo; Terajima, Tomoko; Kizu, Junko; Hori, Seiji.

In: Journal of Infection and Chemotherapy, Vol. 19, No. 5, 10.2013, p. 996-998.

Research output: Contribution to journalArticle

Maezawa, K, Yajima, R, Terajima, T, Kizu, J & Hori, S 2013, 'Dissolution profile of 24 levofloxacin (100 mg) tablets', Journal of Infection and Chemotherapy, vol. 19, no. 5, pp. 996-998. https://doi.org/10.1007/s10156-012-0530-4
Maezawa, Kayoko ; Yajima, Ryo ; Terajima, Tomoko ; Kizu, Junko ; Hori, Seiji. / Dissolution profile of 24 levofloxacin (100 mg) tablets. In: Journal of Infection and Chemotherapy. 2013 ; Vol. 19, No. 5. pp. 996-998.
@article{24c41af3272641378282919e5aa4a0b7,
title = "Dissolution profile of 24 levofloxacin (100 mg) tablets",
abstract = "Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.",
keywords = "Brand name, Dissolution, Generic, Levofloxacin, Tablet",
author = "Kayoko Maezawa and Ryo Yajima and Tomoko Terajima and Junko Kizu and Seiji Hori",
year = "2013",
month = "10",
doi = "10.1007/s10156-012-0530-4",
language = "English",
volume = "19",
pages = "996--998",
journal = "Journal of Infection and Chemotherapy",
issn = "1341-321X",
publisher = "Elsevier BV",
number = "5",

}

TY - JOUR

T1 - Dissolution profile of 24 levofloxacin (100 mg) tablets

AU - Maezawa, Kayoko

AU - Yajima, Ryo

AU - Terajima, Tomoko

AU - Kizu, Junko

AU - Hori, Seiji

PY - 2013/10

Y1 - 2013/10

N2 - Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.

AB - Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.

KW - Brand name

KW - Dissolution

KW - Generic

KW - Levofloxacin

KW - Tablet

UR - http://www.scopus.com/inward/record.url?scp=84885957045&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885957045&partnerID=8YFLogxK

U2 - 10.1007/s10156-012-0530-4

DO - 10.1007/s10156-012-0530-4

M3 - Article

C2 - 23380968

AN - SCOPUS:84885957045

VL - 19

SP - 996

EP - 998

JO - Journal of Infection and Chemotherapy

JF - Journal of Infection and Chemotherapy

SN - 1341-321X

IS - 5

ER -