Dissolution profile of 24 levofloxacin (100 mg) tablets

Kayoko Maezawa, Ryo Yajima, Tomoko Terajima, Junko Kizu, Seiji Hori

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although there are 23 generic levofloxacin (100 mg) tablets (LVFX tablets) and 1 brand name LVFX tablet (supply now discontinued) in Japan, there have been no reports that have evaluated and compared the dissolution profiles of LVFX tablets using the same dissolution method. We studied the dissolution profile of LVFX tablets by the Paddle method, a standard dissolution test method. Among 23 generic LVFX tablets, 2 LVFX tablets had lower dissolution rates and 14 had higher dissolution rates than the brand name LVFX tablet. It is suggested that LVFX tablets have different dissolution profiles, which could cause different pharmacokinetic profiles.

Original languageEnglish
Pages (from-to)996-998
Number of pages3
JournalJournal of Infection and Chemotherapy
Volume19
Issue number5
DOIs
Publication statusPublished - 2013 Oct

Keywords

  • Brand name
  • Dissolution
  • Generic
  • Levofloxacin
  • Tablet

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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