Distinct breast cancer characteristics between screen- and self-detected breast cancers recorded in the Japanese Breast Cancer Registry

Takayuki Iwamoto, Hiraku Kumamaru, Hiroaki Miyata, Ai Tomotaki, Naoki Niikura, Masaaki Kawai, Keisei Anan, Naoki Hayashi, Shinobu Masuda, Koichiro Tsugawa, Kenjiro Aogi, Takanori Ishida, Hideji Masuoka, Kotaro Iijima, Junji Matsuoka, Hiroyoshi Doihara, Takayuki Kinoshita, Seigo Nakamura, Yutaka Tokuda

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The rate of breast cancer screening for women of all ages in Japan is increasing. However, little is known about the biological differences between screen- and self-detected tumors. We used data from the Japanese Breast Cancer Registry (JBCR), a nationwide registry of newly diagnosed breast cancer cases in Japan, to investigate patients diagnosed between January 1, 2004 and December 31, 2011. We compared the clinicopathological features of tumors and assessed yearly trends regarding the proportion of screen-detected cases during the study period. We found that 31.8 % (65,358/205,544) of cancers were detected by screening. Asymptomatic tumors detected by screening (asymptomatic) were more likely to have favorable prognostic features than those that were self-detected (ductal carcinoma in situ [DCIS]: 19.8 versus 4.1 %, node-negative: 77.0 versus 61.6 %, and estrogen receptor-positive [ER+]: 82.0 versus 72.9 %, respectively). All these findings were statistically significant (p < .001). The proportion of breast cancers detected by screening among all cases increased from 21.7 % in 2004 to 37.1 % in 2011. During the same time period, the proportion of screen-detected DCIS increased from 41.5 to 66.0 % and that of ER+ cancers increased from 23.2 to 39.7 %. This study demonstrated that low-risk tumors, including DCIS, ER+, and lower TNM stage, account for a substantial proportion of clinical screening-detected cancers. The differences in biological characteristics between screen- and self-detected cancers may account in part for the limited efficacy of breast cancer screening programs aimed at improving breast cancer mortality.

Original languageEnglish
Pages (from-to)485-494
Number of pages10
JournalBreast Cancer Research and Treatment
Volume156
Issue number3
DOIs
Publication statusPublished - 2016 Apr 1
Externally publishedYes

Fingerprint

Registries
Breast Neoplasms
Early Detection of Cancer
Carcinoma, Intraductal, Noninfiltrating
Neoplasms
Japan
Estrogen Receptors
Mortality

Keywords

  • DCIS
  • Estrogen receptor
  • Japanese Breast Cancer Registry
  • Screening
  • Yearly trend

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Distinct breast cancer characteristics between screen- and self-detected breast cancers recorded in the Japanese Breast Cancer Registry. / Iwamoto, Takayuki; Kumamaru, Hiraku; Miyata, Hiroaki; Tomotaki, Ai; Niikura, Naoki; Kawai, Masaaki; Anan, Keisei; Hayashi, Naoki; Masuda, Shinobu; Tsugawa, Koichiro; Aogi, Kenjiro; Ishida, Takanori; Masuoka, Hideji; Iijima, Kotaro; Matsuoka, Junji; Doihara, Hiroyoshi; Kinoshita, Takayuki; Nakamura, Seigo; Tokuda, Yutaka.

In: Breast Cancer Research and Treatment, Vol. 156, No. 3, 01.04.2016, p. 485-494.

Research output: Contribution to journalArticle

Iwamoto, T, Kumamaru, H, Miyata, H, Tomotaki, A, Niikura, N, Kawai, M, Anan, K, Hayashi, N, Masuda, S, Tsugawa, K, Aogi, K, Ishida, T, Masuoka, H, Iijima, K, Matsuoka, J, Doihara, H, Kinoshita, T, Nakamura, S & Tokuda, Y 2016, 'Distinct breast cancer characteristics between screen- and self-detected breast cancers recorded in the Japanese Breast Cancer Registry', Breast Cancer Research and Treatment, vol. 156, no. 3, pp. 485-494. https://doi.org/10.1007/s10549-016-3770-7
Iwamoto, Takayuki ; Kumamaru, Hiraku ; Miyata, Hiroaki ; Tomotaki, Ai ; Niikura, Naoki ; Kawai, Masaaki ; Anan, Keisei ; Hayashi, Naoki ; Masuda, Shinobu ; Tsugawa, Koichiro ; Aogi, Kenjiro ; Ishida, Takanori ; Masuoka, Hideji ; Iijima, Kotaro ; Matsuoka, Junji ; Doihara, Hiroyoshi ; Kinoshita, Takayuki ; Nakamura, Seigo ; Tokuda, Yutaka. / Distinct breast cancer characteristics between screen- and self-detected breast cancers recorded in the Japanese Breast Cancer Registry. In: Breast Cancer Research and Treatment. 2016 ; Vol. 156, No. 3. pp. 485-494.
@article{845dca3c941e456c82951ceed8be0c47,
title = "Distinct breast cancer characteristics between screen- and self-detected breast cancers recorded in the Japanese Breast Cancer Registry",
abstract = "The rate of breast cancer screening for women of all ages in Japan is increasing. However, little is known about the biological differences between screen- and self-detected tumors. We used data from the Japanese Breast Cancer Registry (JBCR), a nationwide registry of newly diagnosed breast cancer cases in Japan, to investigate patients diagnosed between January 1, 2004 and December 31, 2011. We compared the clinicopathological features of tumors and assessed yearly trends regarding the proportion of screen-detected cases during the study period. We found that 31.8 {\%} (65,358/205,544) of cancers were detected by screening. Asymptomatic tumors detected by screening (asymptomatic) were more likely to have favorable prognostic features than those that were self-detected (ductal carcinoma in situ [DCIS]: 19.8 versus 4.1 {\%}, node-negative: 77.0 versus 61.6 {\%}, and estrogen receptor-positive [ER+]: 82.0 versus 72.9 {\%}, respectively). All these findings were statistically significant (p < .001). The proportion of breast cancers detected by screening among all cases increased from 21.7 {\%} in 2004 to 37.1 {\%} in 2011. During the same time period, the proportion of screen-detected DCIS increased from 41.5 to 66.0 {\%} and that of ER+ cancers increased from 23.2 to 39.7 {\%}. This study demonstrated that low-risk tumors, including DCIS, ER+, and lower TNM stage, account for a substantial proportion of clinical screening-detected cancers. The differences in biological characteristics between screen- and self-detected cancers may account in part for the limited efficacy of breast cancer screening programs aimed at improving breast cancer mortality.",
keywords = "DCIS, Estrogen receptor, Japanese Breast Cancer Registry, Screening, Yearly trend",
author = "Takayuki Iwamoto and Hiraku Kumamaru and Hiroaki Miyata and Ai Tomotaki and Naoki Niikura and Masaaki Kawai and Keisei Anan and Naoki Hayashi and Shinobu Masuda and Koichiro Tsugawa and Kenjiro Aogi and Takanori Ishida and Hideji Masuoka and Kotaro Iijima and Junji Matsuoka and Hiroyoshi Doihara and Takayuki Kinoshita and Seigo Nakamura and Yutaka Tokuda",
year = "2016",
month = "4",
day = "1",
doi = "10.1007/s10549-016-3770-7",
language = "English",
volume = "156",
pages = "485--494",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Distinct breast cancer characteristics between screen- and self-detected breast cancers recorded in the Japanese Breast Cancer Registry

AU - Iwamoto, Takayuki

AU - Kumamaru, Hiraku

AU - Miyata, Hiroaki

AU - Tomotaki, Ai

AU - Niikura, Naoki

AU - Kawai, Masaaki

AU - Anan, Keisei

AU - Hayashi, Naoki

AU - Masuda, Shinobu

AU - Tsugawa, Koichiro

AU - Aogi, Kenjiro

AU - Ishida, Takanori

AU - Masuoka, Hideji

AU - Iijima, Kotaro

AU - Matsuoka, Junji

AU - Doihara, Hiroyoshi

AU - Kinoshita, Takayuki

AU - Nakamura, Seigo

AU - Tokuda, Yutaka

PY - 2016/4/1

Y1 - 2016/4/1

N2 - The rate of breast cancer screening for women of all ages in Japan is increasing. However, little is known about the biological differences between screen- and self-detected tumors. We used data from the Japanese Breast Cancer Registry (JBCR), a nationwide registry of newly diagnosed breast cancer cases in Japan, to investigate patients diagnosed between January 1, 2004 and December 31, 2011. We compared the clinicopathological features of tumors and assessed yearly trends regarding the proportion of screen-detected cases during the study period. We found that 31.8 % (65,358/205,544) of cancers were detected by screening. Asymptomatic tumors detected by screening (asymptomatic) were more likely to have favorable prognostic features than those that were self-detected (ductal carcinoma in situ [DCIS]: 19.8 versus 4.1 %, node-negative: 77.0 versus 61.6 %, and estrogen receptor-positive [ER+]: 82.0 versus 72.9 %, respectively). All these findings were statistically significant (p < .001). The proportion of breast cancers detected by screening among all cases increased from 21.7 % in 2004 to 37.1 % in 2011. During the same time period, the proportion of screen-detected DCIS increased from 41.5 to 66.0 % and that of ER+ cancers increased from 23.2 to 39.7 %. This study demonstrated that low-risk tumors, including DCIS, ER+, and lower TNM stage, account for a substantial proportion of clinical screening-detected cancers. The differences in biological characteristics between screen- and self-detected cancers may account in part for the limited efficacy of breast cancer screening programs aimed at improving breast cancer mortality.

AB - The rate of breast cancer screening for women of all ages in Japan is increasing. However, little is known about the biological differences between screen- and self-detected tumors. We used data from the Japanese Breast Cancer Registry (JBCR), a nationwide registry of newly diagnosed breast cancer cases in Japan, to investigate patients diagnosed between January 1, 2004 and December 31, 2011. We compared the clinicopathological features of tumors and assessed yearly trends regarding the proportion of screen-detected cases during the study period. We found that 31.8 % (65,358/205,544) of cancers were detected by screening. Asymptomatic tumors detected by screening (asymptomatic) were more likely to have favorable prognostic features than those that were self-detected (ductal carcinoma in situ [DCIS]: 19.8 versus 4.1 %, node-negative: 77.0 versus 61.6 %, and estrogen receptor-positive [ER+]: 82.0 versus 72.9 %, respectively). All these findings were statistically significant (p < .001). The proportion of breast cancers detected by screening among all cases increased from 21.7 % in 2004 to 37.1 % in 2011. During the same time period, the proportion of screen-detected DCIS increased from 41.5 to 66.0 % and that of ER+ cancers increased from 23.2 to 39.7 %. This study demonstrated that low-risk tumors, including DCIS, ER+, and lower TNM stage, account for a substantial proportion of clinical screening-detected cancers. The differences in biological characteristics between screen- and self-detected cancers may account in part for the limited efficacy of breast cancer screening programs aimed at improving breast cancer mortality.

KW - DCIS

KW - Estrogen receptor

KW - Japanese Breast Cancer Registry

KW - Screening

KW - Yearly trend

UR - http://www.scopus.com/inward/record.url?scp=84962726199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962726199&partnerID=8YFLogxK

U2 - 10.1007/s10549-016-3770-7

DO - 10.1007/s10549-016-3770-7

M3 - Article

VL - 156

SP - 485

EP - 494

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 3

ER -