Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake

Jonathan Gaucher, Kenichiro Kinouchi, Nicholas Ceglia, Emilie Montellier, Shahaf Peleg, Carolina Magdalen Greco, Andreas Schmidt, Ignasi Forne, Selma Masri, Pierre Baldi, Axel Imhof, Paolo Sassone-Corsi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Binge drinking and chronic exposure to ethanol contribute to alcoholic liver diseases (ALDs). A potential link between ALDs and circadian disruption has been observed, though how different patterns of alcohol consumption differentially impact hepatic circadian metabolism remains virtually unexplored. Using acute versus chronic ethanol feeding, we reveal differential reprogramming of the circadian transcriptome in the liver. Specifically, rewiring of diurnal SREBP transcriptional pathway leads to distinct hepatic signatures in acetyl- CoA metabolism that are translated into the subcellular patterns of protein acetylation. Thus, distinct drinking patterns of alcohol dictate differential adaptation of hepatic circadian metabolism.

Original languageEnglish
Pages (from-to)25250-25259
Number of pages10
JournalProceedings of the National Academy of Sciences of the United States of America
Volume116
Issue number50
DOIs
Publication statusPublished - 2019 Dec 10

Keywords

  • Acetylation
  • Alcohol
  • Circadian
  • Liver
  • Metabolism

ASJC Scopus subject areas

  • General

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    Gaucher, J., Kinouchi, K., Ceglia, N., Montellier, E., Peleg, S., Greco, C. M., Schmidt, A., Forne, I., Masri, S., Baldi, P., Imhof, A., & Sassone-Corsi, P. (2019). Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake. Proceedings of the National Academy of Sciences of the United States of America, 116(50), 25250-25259. https://doi.org/10.1073/pnas.1911189116