Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis

Sangho Jeong, Eunyoung Choi, Christine P. Petersen, Joseph T. Roland, Alessandro Federico, Rossana Ippolito, Francesco P. D'Armiento, Gerardo Nardone, Osamu Nagano, Hideyuki Saya, Marco Romano, James R. Goldenring

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10 Citations (Scopus)

Abstract

Background: Autoimmune gastritis (AIG) and adenocarcinoma-associated chronic atrophic gastritis (CAG) are both associated with oxyntic atrophy, but AIG patients demonstrate an increased risk of carcinoid tumors rather than the elevated risk of adenocarcinoma observed with CAG. We therefore sought to compare the characteristics of the metaplastic mucosa in AIG and CAG patients. Methods: We examined markers for metaplasia (spasmolytic polypeptide expressing metaplasia (SPEM) and intestinal metaplasia) as well as proliferation (Ki67) and immune cell populations (neutrophils, macrophages, and eosinophils) in gastric sections from 16 female patients with autoimmune thyroiditis and AIG and 17 patients with CAG associated with gastric adenocarcinoma. Results: Both AIG and CAG patients demonstrated prominent SPEM and intestinal metaplasia. However, AIG patients displayed significantly lower numbers of infiltrating macrophages and significantly reduced mucosal cell proliferation as compared to CAG patients. Conclusions: These findings indicate that, while both AIG and CAG patients display prominent oxyntic atrophy and metaplasia, the AIG patients do not show proliferative metaplastic lineages that would predispose to adenocarcinoma.

Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalUnited European Gastroenterology Journal
Volume5
Issue number1
DOIs
Publication statusPublished - 2017

Keywords

  • CD44 variant 9
  • DMBT1
  • gastritis
  • intestinal metaplasia
  • macrophage
  • neutrophil
  • Spasmolytic polypeptide-expressing metaplasia

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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    Jeong, S., Choi, E., Petersen, C. P., Roland, J. T., Federico, A., Ippolito, R., D'Armiento, F. P., Nardone, G., Nagano, O., Saya, H., Romano, M., & Goldenring, J. R. (2017). Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis. United European Gastroenterology Journal, 5(1), 37-44. https://doi.org/10.1177/2050640616644142