Distinct neuropsychological profiles of three major symptom dimensions in obsessive-compulsive disorder

Nobuhiko Hashimoto, Shutaro Nakaaki, Ichiro M. Omori, Junko Fujioi, Yuka Noguchi, Yoshie Murata, Junko Sato, Hiroshi Tatsumi, Katsuyoshi Torii, Masaru Mimura, Toshi A. Furukawa

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Recent neuroimaging studies have suggested that different symptom dimensions are mediated by partially distinct neural systems in obsessive-compulsive disorder (OCD). However, the correlations between neuropsychological profiles and symptom dimensions in OCD are unknown. The aim of this study was to examine the extent to which OCD symptom dimensions were associated with episodic memory and attention and executive functions. The symptom dimensions of 63 patients with OCD were assessed using both the Padua Inventory and the Y-BOCS symptom checklist. Then, we administered the Logical Memory (LM) subset of the Wechsler Memory Scale-Revised (WMR-R) test and evaluated inhibition (Stroop test, Trail Making test) and cognitive flexibility (Digit Symbol test, Letter Fluency, and Category Fluency). While associations were observed between scores on the contamination/cleaning dimension and better performances on the LM and Trail Making tests, associations were also observed between scores on the aggressive/checking dimension and poorer performances on the Trail Making test. In addition, we found that scores on the symmetry/ordering dimension were associated with poorer performances on the LM and Trail Making tests. Our results support the hypothesis that different symptoms may represent distinct and partially overlapping neurocognitive networks in OCD patients.

Original languageEnglish
Pages (from-to)166-173
Number of pages8
JournalPsychiatry Research
Volume187
Issue number1-2
DOIs
Publication statusPublished - 2011 May 15
Externally publishedYes

Fingerprint

Obsessive-Compulsive Disorder
Trail Making Test
Stroop Test
Wechsler Scales
Episodic Memory
Executive Function
Checklist
Neuroimaging
Equipment and Supplies

Keywords

  • Attention and executive functions
  • Neuropsychological profiles
  • Obsessions/checking
  • Obsessive-compulsive disorder
  • Padua Inventory
  • Symmetry/ordering
  • Verbal memory
  • Y-BOCS symptom checklist

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Hashimoto, N., Nakaaki, S., Omori, I. M., Fujioi, J., Noguchi, Y., Murata, Y., ... Furukawa, T. A. (2011). Distinct neuropsychological profiles of three major symptom dimensions in obsessive-compulsive disorder. Psychiatry Research, 187(1-2), 166-173. https://doi.org/10.1016/j.psychres.2010.08.001

Distinct neuropsychological profiles of three major symptom dimensions in obsessive-compulsive disorder. / Hashimoto, Nobuhiko; Nakaaki, Shutaro; Omori, Ichiro M.; Fujioi, Junko; Noguchi, Yuka; Murata, Yoshie; Sato, Junko; Tatsumi, Hiroshi; Torii, Katsuyoshi; Mimura, Masaru; Furukawa, Toshi A.

In: Psychiatry Research, Vol. 187, No. 1-2, 15.05.2011, p. 166-173.

Research output: Contribution to journalArticle

Hashimoto, N, Nakaaki, S, Omori, IM, Fujioi, J, Noguchi, Y, Murata, Y, Sato, J, Tatsumi, H, Torii, K, Mimura, M & Furukawa, TA 2011, 'Distinct neuropsychological profiles of three major symptom dimensions in obsessive-compulsive disorder', Psychiatry Research, vol. 187, no. 1-2, pp. 166-173. https://doi.org/10.1016/j.psychres.2010.08.001
Hashimoto, Nobuhiko ; Nakaaki, Shutaro ; Omori, Ichiro M. ; Fujioi, Junko ; Noguchi, Yuka ; Murata, Yoshie ; Sato, Junko ; Tatsumi, Hiroshi ; Torii, Katsuyoshi ; Mimura, Masaru ; Furukawa, Toshi A. / Distinct neuropsychological profiles of three major symptom dimensions in obsessive-compulsive disorder. In: Psychiatry Research. 2011 ; Vol. 187, No. 1-2. pp. 166-173.
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