Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat

Toshihiko Shimizu, Haruki Toriumi, Hideki Sato, Mamoru Shibata, Eiichiro Nagata, Kyoko Gotoh, Norihiro Suzuki

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

We examined the distribution and origin of the nerve fibers innervating the dura mater of the rat that show immunoreactivity for the TRPV1 receptor (TRPV1-IR). Nearly 70% of the nerve fibers showing TRPV1-IR in the dura mater also exhibited CGRP-IR. Using a combination of immunohistochemistry and a retrograde tracer technique, we detected tracer accumulation in 0.6% of the neurons in the trigeminal ganglion and a few neurons in the dorsal root ganglion; half of the neurons in the trigeminal ganglion were small- and medium-sized (≤ 1000 μm2). Among the tracer-accumulated neurons in the trigeminal ganglion, approximately 25% exhibited TRPV1-IR. Furthermore, nearly 80% of the tracer-accumulated small- and medium-sized neurons in the trigeminal ganglion that exhibited TRPV1-IR also exhibited CGRP-IR. Our findings indicate that the TRPV1 receptor in the dura mater and sensory ganglia may contribute to the pathophysiology of migraine, providing an important clue for the development of therapeutic strategies for migraine.

Original languageEnglish
Pages (from-to)84-91
Number of pages8
JournalBrain Research
Volume1173
Issue number1
DOIs
Publication statusPublished - 2007 Oct 10

Fingerprint

Dura Mater
Trigeminal Ganglion
Nerve Fibers
Neurons
Migraine Disorders
Sensory Ganglia
Spinal Ganglia
Immunohistochemistry
TRPV1 receptor

Keywords

  • CGRP
  • Dura mater
  • Migraine
  • Nociception
  • Trigeminal ganglion
  • TRPV1 receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat. / Shimizu, Toshihiko; Toriumi, Haruki; Sato, Hideki; Shibata, Mamoru; Nagata, Eiichiro; Gotoh, Kyoko; Suzuki, Norihiro.

In: Brain Research, Vol. 1173, No. 1, 10.10.2007, p. 84-91.

Research output: Contribution to journalArticle

Shimizu, Toshihiko ; Toriumi, Haruki ; Sato, Hideki ; Shibata, Mamoru ; Nagata, Eiichiro ; Gotoh, Kyoko ; Suzuki, Norihiro. / Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat. In: Brain Research. 2007 ; Vol. 1173, No. 1. pp. 84-91.
@article{f55ad9d3f8d549b3a7a7ec2fd20580f8,
title = "Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat",
abstract = "We examined the distribution and origin of the nerve fibers innervating the dura mater of the rat that show immunoreactivity for the TRPV1 receptor (TRPV1-IR). Nearly 70{\%} of the nerve fibers showing TRPV1-IR in the dura mater also exhibited CGRP-IR. Using a combination of immunohistochemistry and a retrograde tracer technique, we detected tracer accumulation in 0.6{\%} of the neurons in the trigeminal ganglion and a few neurons in the dorsal root ganglion; half of the neurons in the trigeminal ganglion were small- and medium-sized (≤ 1000 μm2). Among the tracer-accumulated neurons in the trigeminal ganglion, approximately 25{\%} exhibited TRPV1-IR. Furthermore, nearly 80{\%} of the tracer-accumulated small- and medium-sized neurons in the trigeminal ganglion that exhibited TRPV1-IR also exhibited CGRP-IR. Our findings indicate that the TRPV1 receptor in the dura mater and sensory ganglia may contribute to the pathophysiology of migraine, providing an important clue for the development of therapeutic strategies for migraine.",
keywords = "CGRP, Dura mater, Migraine, Nociception, Trigeminal ganglion, TRPV1 receptor",
author = "Toshihiko Shimizu and Haruki Toriumi and Hideki Sato and Mamoru Shibata and Eiichiro Nagata and Kyoko Gotoh and Norihiro Suzuki",
year = "2007",
month = "10",
day = "10",
doi = "10.1016/j.brainres.2007.07.068",
language = "English",
volume = "1173",
pages = "84--91",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat

AU - Shimizu, Toshihiko

AU - Toriumi, Haruki

AU - Sato, Hideki

AU - Shibata, Mamoru

AU - Nagata, Eiichiro

AU - Gotoh, Kyoko

AU - Suzuki, Norihiro

PY - 2007/10/10

Y1 - 2007/10/10

N2 - We examined the distribution and origin of the nerve fibers innervating the dura mater of the rat that show immunoreactivity for the TRPV1 receptor (TRPV1-IR). Nearly 70% of the nerve fibers showing TRPV1-IR in the dura mater also exhibited CGRP-IR. Using a combination of immunohistochemistry and a retrograde tracer technique, we detected tracer accumulation in 0.6% of the neurons in the trigeminal ganglion and a few neurons in the dorsal root ganglion; half of the neurons in the trigeminal ganglion were small- and medium-sized (≤ 1000 μm2). Among the tracer-accumulated neurons in the trigeminal ganglion, approximately 25% exhibited TRPV1-IR. Furthermore, nearly 80% of the tracer-accumulated small- and medium-sized neurons in the trigeminal ganglion that exhibited TRPV1-IR also exhibited CGRP-IR. Our findings indicate that the TRPV1 receptor in the dura mater and sensory ganglia may contribute to the pathophysiology of migraine, providing an important clue for the development of therapeutic strategies for migraine.

AB - We examined the distribution and origin of the nerve fibers innervating the dura mater of the rat that show immunoreactivity for the TRPV1 receptor (TRPV1-IR). Nearly 70% of the nerve fibers showing TRPV1-IR in the dura mater also exhibited CGRP-IR. Using a combination of immunohistochemistry and a retrograde tracer technique, we detected tracer accumulation in 0.6% of the neurons in the trigeminal ganglion and a few neurons in the dorsal root ganglion; half of the neurons in the trigeminal ganglion were small- and medium-sized (≤ 1000 μm2). Among the tracer-accumulated neurons in the trigeminal ganglion, approximately 25% exhibited TRPV1-IR. Furthermore, nearly 80% of the tracer-accumulated small- and medium-sized neurons in the trigeminal ganglion that exhibited TRPV1-IR also exhibited CGRP-IR. Our findings indicate that the TRPV1 receptor in the dura mater and sensory ganglia may contribute to the pathophysiology of migraine, providing an important clue for the development of therapeutic strategies for migraine.

KW - CGRP

KW - Dura mater

KW - Migraine

KW - Nociception

KW - Trigeminal ganglion

KW - TRPV1 receptor

UR - http://www.scopus.com/inward/record.url?scp=34548850359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548850359&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2007.07.068

DO - 10.1016/j.brainres.2007.07.068

M3 - Article

C2 - 17765209

AN - SCOPUS:34548850359

VL - 1173

SP - 84

EP - 91

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -