Disturbance response analysis of cell-to-cell communication systems based on spatial frequency decomposition

Taishi Kotsuka, Yutaka Hori

Research output: Contribution to journalConference article

Abstract

In biomolecular communication networks, bacterial cells communicate with each other using a cell-to-cell communication mechanism mediated by diffusible signaling molecules. The dynamics of molecular concentrations in such systems are approximately modeled by reaction-diffusion equations. In this paper, we analyze the ability of cell-to-cell communication systems to attenuate impulsive disturbances with various spatial frequency profiles by computing the integrated squared concentration of molecules. In particular, we perform in-depth study of disturbance responses for an activator-repressor-diffuser biocircuit in the spatial frequency domain to characterize its spatial frequency gain.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalIFAC-PapersOnLine
Volume52
Issue number26
DOIs
Publication statusPublished - 2019 Jan 1
Event8th Conference on Foundations of Systems Biology in Engineering, FOSBE 2019 - Valencia, Spain
Duration: 2019 Oct 152019 Oct 18

Keywords

  • activator-repressor-diffuser model
  • cell-to-cell communication
  • disturbance response
  • reaction-diffusion system
  • synthetic biology

ASJC Scopus subject areas

  • Control and Systems Engineering

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