Divergent effects of unilateral and subtotal nephrectomy on insulin sensitivity in rats

Yoshiyuki Kato, Yoichi Ohno, Matsuhiko Hayashi, Taichi Suzawa, Keigo Shibagaki, Takayuki Sasaki, Takao Saruta

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives. Insulin resistance is associated with chronic renal failure, which may amplify its cardiovascular pathologic manifestations. We previously showed the presence of insulin resistance in mild renal insufficiency due to chronic glomerulonephritis. These observations may be explained by a decrease in insulin sensitivity due to renal dysfunction. The aim of the present study was to evaluate the effects of unilateral and subtotal nephrectomy on insulin sensitivity. Methods. Unilateral heminephrectomy and five-sixths nephrectomy (5/6Nx) were performed in male Sprague-Dawley rats, measuring steady-state plasma glucose (SSPG) during the insulin suppression test. Results. The glomerular filtration rate (GFR) decreased significantly from sham-operated rats, to unilateral heminephrectomy group, to 5/6Nx rats. SSPG was-unexpectedly lower in the unilateral heminephrectomy group than-in controls, suggesting that unilateral heminephrectomy increased the sensitivity to insulin despite a mild decrease in renal function. However, when the analysis was limited to the 5/6Nx group, SSPG was inversely correlated with GFR (r=-0.65, p < 0.05). When renal failure caused by 5/6Nx had reached end stage, the rats became insulin resistant, despite a profound reduction in renal mass. Conclusion. It is suggested that unilateral heminephrectomy reduced GFR and increased the sensitivity to insulin. When rats became uremic, insulin sensitivity decreased, even, in 5/6Nx.

Original languageEnglish
Pages (from-to)451-457
Number of pages7
JournalRenal Failure
Volume27
Issue number4
DOIs
Publication statusPublished - 2005

Fingerprint

Nephrectomy
Insulin Resistance
Glomerular Filtration Rate
Kidney
Glucose
Renal Insufficiency
Insulin
Glomerulonephritis
Chronic Kidney Failure
Sprague Dawley Rats
Control Groups

Keywords

  • End-stage renal disease
  • gluconeogenesis
  • Insulin resistance
  • Nephrectomy
  • Steady-state plasma glucose

ASJC Scopus subject areas

  • Nephrology

Cite this

Kato, Y., Ohno, Y., Hayashi, M., Suzawa, T., Shibagaki, K., Sasaki, T., & Saruta, T. (2005). Divergent effects of unilateral and subtotal nephrectomy on insulin sensitivity in rats. Renal Failure, 27(4), 451-457. https://doi.org/10.1081/JDI-65346

Divergent effects of unilateral and subtotal nephrectomy on insulin sensitivity in rats. / Kato, Yoshiyuki; Ohno, Yoichi; Hayashi, Matsuhiko; Suzawa, Taichi; Shibagaki, Keigo; Sasaki, Takayuki; Saruta, Takao.

In: Renal Failure, Vol. 27, No. 4, 2005, p. 451-457.

Research output: Contribution to journalArticle

Kato, Y, Ohno, Y, Hayashi, M, Suzawa, T, Shibagaki, K, Sasaki, T & Saruta, T 2005, 'Divergent effects of unilateral and subtotal nephrectomy on insulin sensitivity in rats', Renal Failure, vol. 27, no. 4, pp. 451-457. https://doi.org/10.1081/JDI-65346
Kato Y, Ohno Y, Hayashi M, Suzawa T, Shibagaki K, Sasaki T et al. Divergent effects of unilateral and subtotal nephrectomy on insulin sensitivity in rats. Renal Failure. 2005;27(4):451-457. https://doi.org/10.1081/JDI-65346
Kato, Yoshiyuki ; Ohno, Yoichi ; Hayashi, Matsuhiko ; Suzawa, Taichi ; Shibagaki, Keigo ; Sasaki, Takayuki ; Saruta, Takao. / Divergent effects of unilateral and subtotal nephrectomy on insulin sensitivity in rats. In: Renal Failure. 2005 ; Vol. 27, No. 4. pp. 451-457.
@article{f7b52074b7ae44ecb30b8c0c0fac6bc5,
title = "Divergent effects of unilateral and subtotal nephrectomy on insulin sensitivity in rats",
abstract = "Objectives. Insulin resistance is associated with chronic renal failure, which may amplify its cardiovascular pathologic manifestations. We previously showed the presence of insulin resistance in mild renal insufficiency due to chronic glomerulonephritis. These observations may be explained by a decrease in insulin sensitivity due to renal dysfunction. The aim of the present study was to evaluate the effects of unilateral and subtotal nephrectomy on insulin sensitivity. Methods. Unilateral heminephrectomy and five-sixths nephrectomy (5/6Nx) were performed in male Sprague-Dawley rats, measuring steady-state plasma glucose (SSPG) during the insulin suppression test. Results. The glomerular filtration rate (GFR) decreased significantly from sham-operated rats, to unilateral heminephrectomy group, to 5/6Nx rats. SSPG was-unexpectedly lower in the unilateral heminephrectomy group than-in controls, suggesting that unilateral heminephrectomy increased the sensitivity to insulin despite a mild decrease in renal function. However, when the analysis was limited to the 5/6Nx group, SSPG was inversely correlated with GFR (r=-0.65, p < 0.05). When renal failure caused by 5/6Nx had reached end stage, the rats became insulin resistant, despite a profound reduction in renal mass. Conclusion. It is suggested that unilateral heminephrectomy reduced GFR and increased the sensitivity to insulin. When rats became uremic, insulin sensitivity decreased, even, in 5/6Nx.",
keywords = "End-stage renal disease, gluconeogenesis, Insulin resistance, Nephrectomy, Steady-state plasma glucose",
author = "Yoshiyuki Kato and Yoichi Ohno and Matsuhiko Hayashi and Taichi Suzawa and Keigo Shibagaki and Takayuki Sasaki and Takao Saruta",
year = "2005",
doi = "10.1081/JDI-65346",
language = "English",
volume = "27",
pages = "451--457",
journal = "Renal Failure",
issn = "0886-022X",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Divergent effects of unilateral and subtotal nephrectomy on insulin sensitivity in rats

AU - Kato, Yoshiyuki

AU - Ohno, Yoichi

AU - Hayashi, Matsuhiko

AU - Suzawa, Taichi

AU - Shibagaki, Keigo

AU - Sasaki, Takayuki

AU - Saruta, Takao

PY - 2005

Y1 - 2005

N2 - Objectives. Insulin resistance is associated with chronic renal failure, which may amplify its cardiovascular pathologic manifestations. We previously showed the presence of insulin resistance in mild renal insufficiency due to chronic glomerulonephritis. These observations may be explained by a decrease in insulin sensitivity due to renal dysfunction. The aim of the present study was to evaluate the effects of unilateral and subtotal nephrectomy on insulin sensitivity. Methods. Unilateral heminephrectomy and five-sixths nephrectomy (5/6Nx) were performed in male Sprague-Dawley rats, measuring steady-state plasma glucose (SSPG) during the insulin suppression test. Results. The glomerular filtration rate (GFR) decreased significantly from sham-operated rats, to unilateral heminephrectomy group, to 5/6Nx rats. SSPG was-unexpectedly lower in the unilateral heminephrectomy group than-in controls, suggesting that unilateral heminephrectomy increased the sensitivity to insulin despite a mild decrease in renal function. However, when the analysis was limited to the 5/6Nx group, SSPG was inversely correlated with GFR (r=-0.65, p < 0.05). When renal failure caused by 5/6Nx had reached end stage, the rats became insulin resistant, despite a profound reduction in renal mass. Conclusion. It is suggested that unilateral heminephrectomy reduced GFR and increased the sensitivity to insulin. When rats became uremic, insulin sensitivity decreased, even, in 5/6Nx.

AB - Objectives. Insulin resistance is associated with chronic renal failure, which may amplify its cardiovascular pathologic manifestations. We previously showed the presence of insulin resistance in mild renal insufficiency due to chronic glomerulonephritis. These observations may be explained by a decrease in insulin sensitivity due to renal dysfunction. The aim of the present study was to evaluate the effects of unilateral and subtotal nephrectomy on insulin sensitivity. Methods. Unilateral heminephrectomy and five-sixths nephrectomy (5/6Nx) were performed in male Sprague-Dawley rats, measuring steady-state plasma glucose (SSPG) during the insulin suppression test. Results. The glomerular filtration rate (GFR) decreased significantly from sham-operated rats, to unilateral heminephrectomy group, to 5/6Nx rats. SSPG was-unexpectedly lower in the unilateral heminephrectomy group than-in controls, suggesting that unilateral heminephrectomy increased the sensitivity to insulin despite a mild decrease in renal function. However, when the analysis was limited to the 5/6Nx group, SSPG was inversely correlated with GFR (r=-0.65, p < 0.05). When renal failure caused by 5/6Nx had reached end stage, the rats became insulin resistant, despite a profound reduction in renal mass. Conclusion. It is suggested that unilateral heminephrectomy reduced GFR and increased the sensitivity to insulin. When rats became uremic, insulin sensitivity decreased, even, in 5/6Nx.

KW - End-stage renal disease

KW - gluconeogenesis

KW - Insulin resistance

KW - Nephrectomy

KW - Steady-state plasma glucose

UR - http://www.scopus.com/inward/record.url?scp=22244486036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22244486036&partnerID=8YFLogxK

U2 - 10.1081/JDI-65346

DO - 10.1081/JDI-65346

M3 - Article

C2 - 16060135

AN - SCOPUS:22244486036

VL - 27

SP - 451

EP - 457

JO - Renal Failure

JF - Renal Failure

SN - 0886-022X

IS - 4

ER -