Dkk4 and eda regulate distinctive developmental mechanisms for subtypes of mouse hair

Chang Yi Cui, Makoto Kunisada, Yulan Piao, Victoria Childress, Minoru Ko, David Schlessinger

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The mouse hair coat comprises protective "primary" and thermo-regulatory "secondary" hairs. Primary hair formation is ectodysplasin (Eda) dependent, but it has been puzzling that Tabby (Eda-/y) mice still make secondary hair. We report that Dickkopf 4 (Dkk4), a Wnt antagonist, affects an auxiliary pathway for Eda-independent development of secondary hair. A Dkk4 transgene in wild-type mice had no effect on primary hair, but secondary hairs were severely malformed. Dkk4 action on secondary hair was further demonstrated when the transgene was introduced into Tabby mice: the usual secondary follicle induction was completely blocked. The Dkk4-regulated secondary hair pathway, like the Eda-dependent primary hair pathway, is further mediated by selective activation of Shh. The results thus reveal two complex molecular pathways that distinctly regulate subtype-based morphogenesis of hair follicles, and provide a resolution for the longstanding puzzle of hair formation in Tabby mice lacking Eda.

Original languageEnglish
Article numbere10009
JournalPLoS One
Volume5
Issue number4
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Ectodysplasins
Hair
hairs
mice
Transgenes
transgenes
Chemical activation
hair follicles
Hair Follicle
Morphogenesis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Cui, C. Y., Kunisada, M., Piao, Y., Childress, V., Ko, M., & Schlessinger, D. (2010). Dkk4 and eda regulate distinctive developmental mechanisms for subtypes of mouse hair. PLoS One, 5(4), [e10009]. https://doi.org/10.1371/journal.pone.0010009

Dkk4 and eda regulate distinctive developmental mechanisms for subtypes of mouse hair. / Cui, Chang Yi; Kunisada, Makoto; Piao, Yulan; Childress, Victoria; Ko, Minoru; Schlessinger, David.

In: PLoS One, Vol. 5, No. 4, e10009, 2010.

Research output: Contribution to journalArticle

Cui, CY, Kunisada, M, Piao, Y, Childress, V, Ko, M & Schlessinger, D 2010, 'Dkk4 and eda regulate distinctive developmental mechanisms for subtypes of mouse hair', PLoS One, vol. 5, no. 4, e10009. https://doi.org/10.1371/journal.pone.0010009
Cui, Chang Yi ; Kunisada, Makoto ; Piao, Yulan ; Childress, Victoria ; Ko, Minoru ; Schlessinger, David. / Dkk4 and eda regulate distinctive developmental mechanisms for subtypes of mouse hair. In: PLoS One. 2010 ; Vol. 5, No. 4.
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