DN-cadherin is required for spatial arrangement of nerve terminals and ultrastructural organization of synapses

Youichi Iwai, Yuki Hirota, Koichi Ozaki, Hideyuki Okano, Masatoshi Takeichi, Tadashi Uemura

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

We studied roles of DN-cadherin, the Drosophila major neuronal cadherin, in neuronal connections in the visual system. In DN-cadherin mutants, axon terminals of a large subset of photoreceptor cells reached and associated with their target interneurons, but their characteristic spatial arrangement was disrupted as synaptogenesis proceeded. Although synapses were formed at contact sites between the axon terminals and target neurons, underlycytoplasmic structures were not fully specialized at both pre- and postsynaptic terminals and synaptic vesicles appeared to accumulate at the presynapses. These results suggest that the cadherin adhesion system is required for interaction between pre- and postsynaptic terminals and for generation of the mature synaptic structures.

Original languageEnglish
Pages (from-to)375-388
Number of pages14
JournalMolecular and Cellular Neuroscience
Volume19
Issue number3
DOIs
Publication statusPublished - 2002
Externally publishedYes

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Presynaptic Terminals
Cadherins
Synapses
Photoreceptor Cells
Synaptic Vesicles
Interneurons
Neurons

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

Cite this

DN-cadherin is required for spatial arrangement of nerve terminals and ultrastructural organization of synapses. / Iwai, Youichi; Hirota, Yuki; Ozaki, Koichi; Okano, Hideyuki; Takeichi, Masatoshi; Uemura, Tadashi.

In: Molecular and Cellular Neuroscience, Vol. 19, No. 3, 2002, p. 375-388.

Research output: Contribution to journalArticle

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