DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group

Teruyuki Kobayashi, Takashi Okuno, Toshio Suzuki, Mami Kunita, Shigeru Ohba, Yuzo Nishida

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Copper-based transition metal complexes which perform single-strand scission of DNA in a site-specific manner have been designed. The complexes Cu(dpg)+ and Cu(dpgt)C1+ (H(dpg) and (dpgt) represent bis(2-pyridylmethyl) derivatives of glycylglycine and glycylglycylglycine, respectively), were prepared in this study and its crystal structures were determined. We have found that Cu(dpgt)C1+ and Cu(dpg)+ complexes convert supercoiled plasmid DNA into a mixture of nicked and linear forms in the presence of hydrogen peroxide, whereas related Cu(II) complexes, which lack a peptide group, produce complete degradation of DNA under the same experimental conditions.

Original languageEnglish
Pages (from-to)1553-1559
Number of pages7
JournalPolyhedron
Volume17
Issue number9
Publication statusPublished - 1998 May 10

Fingerprint

Peptides
peptides
Copper
DNA
deoxyribonucleic acid
Ligands
Glycylglycine
degradation
Superhelical DNA
Degradation
copper
ligands
Coordination Complexes
Hydrogen Peroxide
Plasmids
plasmids
Metal complexes
hydrogen peroxide
Hydrogen peroxide
strands

Keywords

  • Copper(II) and hydrogen peroxide
  • DNA cleavage
  • Supercoiled DNA
  • Tripodal-ligands containing peptide group

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Kobayashi, T., Okuno, T., Suzuki, T., Kunita, M., Ohba, S., & Nishida, Y. (1998). DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group. Polyhedron, 17(9), 1553-1559.

DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group. / Kobayashi, Teruyuki; Okuno, Takashi; Suzuki, Toshio; Kunita, Mami; Ohba, Shigeru; Nishida, Yuzo.

In: Polyhedron, Vol. 17, No. 9, 10.05.1998, p. 1553-1559.

Research output: Contribution to journalArticle

Kobayashi, T, Okuno, T, Suzuki, T, Kunita, M, Ohba, S & Nishida, Y 1998, 'DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group', Polyhedron, vol. 17, no. 9, pp. 1553-1559.
Kobayashi T, Okuno T, Suzuki T, Kunita M, Ohba S, Nishida Y. DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group. Polyhedron. 1998 May 10;17(9):1553-1559.
Kobayashi, Teruyuki ; Okuno, Takashi ; Suzuki, Toshio ; Kunita, Mami ; Ohba, Shigeru ; Nishida, Yuzo. / DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group. In: Polyhedron. 1998 ; Vol. 17, No. 9. pp. 1553-1559.
@article{f2ddec8900a14ccd9bfe50cfb4875fa5,
title = "DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group",
abstract = "Copper-based transition metal complexes which perform single-strand scission of DNA in a site-specific manner have been designed. The complexes Cu(dpg)+ and Cu(dpgt)C1+ (H(dpg) and (dpgt) represent bis(2-pyridylmethyl) derivatives of glycylglycine and glycylglycylglycine, respectively), were prepared in this study and its crystal structures were determined. We have found that Cu(dpgt)C1+ and Cu(dpg)+ complexes convert supercoiled plasmid DNA into a mixture of nicked and linear forms in the presence of hydrogen peroxide, whereas related Cu(II) complexes, which lack a peptide group, produce complete degradation of DNA under the same experimental conditions.",
keywords = "Copper(II) and hydrogen peroxide, DNA cleavage, Supercoiled DNA, Tripodal-ligands containing peptide group",
author = "Teruyuki Kobayashi and Takashi Okuno and Toshio Suzuki and Mami Kunita and Shigeru Ohba and Yuzo Nishida",
year = "1998",
month = "5",
day = "10",
language = "English",
volume = "17",
pages = "1553--1559",
journal = "Polyhedron",
issn = "0277-5387",
publisher = "Elsevier Limited",
number = "9",

}

TY - JOUR

T1 - DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group

AU - Kobayashi, Teruyuki

AU - Okuno, Takashi

AU - Suzuki, Toshio

AU - Kunita, Mami

AU - Ohba, Shigeru

AU - Nishida, Yuzo

PY - 1998/5/10

Y1 - 1998/5/10

N2 - Copper-based transition metal complexes which perform single-strand scission of DNA in a site-specific manner have been designed. The complexes Cu(dpg)+ and Cu(dpgt)C1+ (H(dpg) and (dpgt) represent bis(2-pyridylmethyl) derivatives of glycylglycine and glycylglycylglycine, respectively), were prepared in this study and its crystal structures were determined. We have found that Cu(dpgt)C1+ and Cu(dpg)+ complexes convert supercoiled plasmid DNA into a mixture of nicked and linear forms in the presence of hydrogen peroxide, whereas related Cu(II) complexes, which lack a peptide group, produce complete degradation of DNA under the same experimental conditions.

AB - Copper-based transition metal complexes which perform single-strand scission of DNA in a site-specific manner have been designed. The complexes Cu(dpg)+ and Cu(dpgt)C1+ (H(dpg) and (dpgt) represent bis(2-pyridylmethyl) derivatives of glycylglycine and glycylglycylglycine, respectively), were prepared in this study and its crystal structures were determined. We have found that Cu(dpgt)C1+ and Cu(dpg)+ complexes convert supercoiled plasmid DNA into a mixture of nicked and linear forms in the presence of hydrogen peroxide, whereas related Cu(II) complexes, which lack a peptide group, produce complete degradation of DNA under the same experimental conditions.

KW - Copper(II) and hydrogen peroxide

KW - DNA cleavage

KW - Supercoiled DNA

KW - Tripodal-ligands containing peptide group

UR - http://www.scopus.com/inward/record.url?scp=0000866716&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0000866716&partnerID=8YFLogxK

M3 - Article

VL - 17

SP - 1553

EP - 1559

JO - Polyhedron

JF - Polyhedron

SN - 0277-5387

IS - 9

ER -