DNA degradation by the copper(II) complex with tripodal-ligands containing peptide group

Teruyuki Kobayashi, Takashi Okuno, Toshio Suzuki, Mami Kunita, Shigeru Ohba, Yuzo Nishida

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Copper-based transition metal complexes which perform single-strand scission of DNA in a site-specific manner have been designed. The complexes Cu(dpg)+ and Cu(dpgt)C1+ (H(dpg) and (dpgt) represent bis(2-pyridylmethyl) derivatives of glycylglycine and glycylglycylglycine, respectively), were prepared in this study and its crystal structures were determined. We have found that Cu(dpgt)C1+ and Cu(dpg)+ complexes convert supercoiled plasmid DNA into a mixture of nicked and linear forms in the presence of hydrogen peroxide, whereas related Cu(II) complexes, which lack a peptide group, produce complete degradation of DNA under the same experimental conditions.

Original languageEnglish
Pages (from-to)1553-1559
Number of pages7
JournalPolyhedron
Volume17
Issue number9
DOIs
Publication statusPublished - 1998 May 10

Keywords

  • Copper(II) and hydrogen peroxide
  • DNA cleavage
  • Supercoiled DNA
  • Tripodal-ligands containing peptide group

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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