Do doctors know of and use PK-PD-based antimicrobial agent dosage?

Junko Kizu, Satoshi Iwata, Shinya Kusachi, Junko Sato, Yoshitake Sato, Mitsuru Sandoh, Hiroaki Takeda, Kazuhiro Tateda, Seiji Hori

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Pharmacokinetic-pharmacodynamic(PK-PD) analysis is important in selecting the antimicrobial agent dosage for appropriate use. No information on the spread of dosage determination based on PK-PD analysis has, to our knowledge, been reported. We studied how the PK-PD concept spread in the clinical field. Among respondents, 55% of doctors knew of the PK-PD concept, which 66% evaluated as very useful. They determined the dosage of carbapenems (78% of doctors), aminoglycosides (77%), and injectable cephems (75%) based on the PK-PD concept. Of these doctors, however, 55% determined the dosage of quinolones based on this concept. We suggest that training in PK-PD analysis and dosage determination based on PK-PD is important and urgent in appropriate antimicrobial agent use.

Original languageEnglish
Pages (from-to)460-465
Number of pages6
JournalJapanese Journal of Chemotherapy
Issue number4
Publication statusPublished - 2010 Jul
Externally publishedYes


  • Antimicrobial agents
  • Dosage
  • PK-PD
  • Questionnaire survey

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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