Do doctors know of and use PK-PD-based antimicrobial agent dosage?

Junko Kizu, Satoshi Iwata, Shinya Kusachi, Junko Sato, Yoshitake Sato, Mitsuru Sandoh, Hiroaki Takeda, Kazuhiro Tateda, Seiji Hori

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Pharmacokinetic-pharmacodynamic(PK-PD) analysis is important in selecting the antimicrobial agent dosage for appropriate use. No information on the spread of dosage determination based on PK-PD analysis has, to our knowledge, been reported. We studied how the PK-PD concept spread in the clinical field. Among respondents, 55% of doctors knew of the PK-PD concept, which 66% evaluated as very useful. They determined the dosage of carbapenems (78% of doctors), aminoglycosides (77%), and injectable cephems (75%) based on the PK-PD concept. Of these doctors, however, 55% determined the dosage of quinolones based on this concept. We suggest that training in PK-PD analysis and dosage determination based on PK-PD is important and urgent in appropriate antimicrobial agent use.

Original languageEnglish
Pages (from-to)460-465
Number of pages6
JournalJapanese Journal of Chemotherapy
Volume58
Issue number4
Publication statusPublished - 2010 Jul

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Anti-Infective Agents
Pharmacokinetics
Carbapenems
Quinolones
Aminoglycosides
Injections

Keywords

  • Antimicrobial agents
  • Dosage
  • PK-PD
  • Questionnaire survey

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Kizu, J., Iwata, S., Kusachi, S., Sato, J., Sato, Y., Sandoh, M., ... Hori, S. (2010). Do doctors know of and use PK-PD-based antimicrobial agent dosage? Japanese Journal of Chemotherapy, 58(4), 460-465.

Do doctors know of and use PK-PD-based antimicrobial agent dosage? / Kizu, Junko; Iwata, Satoshi; Kusachi, Shinya; Sato, Junko; Sato, Yoshitake; Sandoh, Mitsuru; Takeda, Hiroaki; Tateda, Kazuhiro; Hori, Seiji.

In: Japanese Journal of Chemotherapy, Vol. 58, No. 4, 07.2010, p. 460-465.

Research output: Contribution to journalArticle

Kizu, J, Iwata, S, Kusachi, S, Sato, J, Sato, Y, Sandoh, M, Takeda, H, Tateda, K & Hori, S 2010, 'Do doctors know of and use PK-PD-based antimicrobial agent dosage?', Japanese Journal of Chemotherapy, vol. 58, no. 4, pp. 460-465.
Kizu J, Iwata S, Kusachi S, Sato J, Sato Y, Sandoh M et al. Do doctors know of and use PK-PD-based antimicrobial agent dosage? Japanese Journal of Chemotherapy. 2010 Jul;58(4):460-465.
Kizu, Junko ; Iwata, Satoshi ; Kusachi, Shinya ; Sato, Junko ; Sato, Yoshitake ; Sandoh, Mitsuru ; Takeda, Hiroaki ; Tateda, Kazuhiro ; Hori, Seiji. / Do doctors know of and use PK-PD-based antimicrobial agent dosage?. In: Japanese Journal of Chemotherapy. 2010 ; Vol. 58, No. 4. pp. 460-465.
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