Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation

Tomohisa Egawa, Tetsuro Kubota, Akihiko Suto, Yoshihide Otani, Toshiharu Furukawa, Masahiko Watanabe, Koichiro Kumai, Masaki Kitajima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We assessed the combined antitumor activity of docetaxel and doxorubicin (DXR) and tetrahydropyranyladriamycin (THP) using the human breast carcinoma cell lines R-27 and MDA-MB-231. Synergistic antitumor activity was observed for both combined docetaxel and DXR, and docetaxel and THP against R-27 cells when contacted simultaneously. However, only additive effects were observed against MDA-MB-231 cells. Intracellular concentrations of DXR and THP in R-27 cells were significantly increased by docetaxel pretreatment, however, this increase was not observed in MDA-MB-231 cells, which exhibited only additive sensitivity to the treatment. Thus, docetaxel increased the antitumor activity of anthracyclines by increasing their intracellular concentrations.

Original languageEnglish
Pages (from-to)777-781
Number of pages5
JournalOncology Reports
Volume9
Issue number4
Publication statusPublished - 2002 Jul

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docetaxel
Anthracyclines
Doxorubicin
Pharmaceutical Preparations
Breast Neoplasms
Cell Line

Keywords

  • Breast cancer
  • Combination therapy
  • Docetaxel
  • Doxorubicin
  • Intracellular concentration
  • Synergism
  • Tetrahydropyranyladriamycin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Egawa, T., Kubota, T., Suto, A., Otani, Y., Furukawa, T., Watanabe, M., ... Kitajima, M. (2002). Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation. Oncology Reports, 9(4), 777-781.

Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation. / Egawa, Tomohisa; Kubota, Tetsuro; Suto, Akihiko; Otani, Yoshihide; Furukawa, Toshiharu; Watanabe, Masahiko; Kumai, Koichiro; Kitajima, Masaki.

In: Oncology Reports, Vol. 9, No. 4, 07.2002, p. 777-781.

Research output: Contribution to journalArticle

Egawa, T, Kubota, T, Suto, A, Otani, Y, Furukawa, T, Watanabe, M, Kumai, K & Kitajima, M 2002, 'Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation', Oncology Reports, vol. 9, no. 4, pp. 777-781.
Egawa, Tomohisa ; Kubota, Tetsuro ; Suto, Akihiko ; Otani, Yoshihide ; Furukawa, Toshiharu ; Watanabe, Masahiko ; Kumai, Koichiro ; Kitajima, Masaki. / Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation. In: Oncology Reports. 2002 ; Vol. 9, No. 4. pp. 777-781.
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AU - Watanabe, Masahiko

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