Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation

Tomohisa Egawa; Tetsuro Kubota; Akihiko Suto; Yoshihide Otani; Toshiharu Furukawa; Masahiko Watanabe; Koichiro Kumai; Masaki Kitajima

doi:10.3892/or.9.4.777

Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation

Tomohisa Egawa, Tetsuro Kubota, Akihiko Suto, Yoshihide Otani, Toshiharu Furukawa, Masahiko Watanabe, Koichiro Kumai, Masaki Kitajima

Law School

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We assessed the combined antitumor activity of docetaxel and doxorubicin (DXR) and tetrahydropyranyladriamycin (THP) using the human breast carcinoma cell lines R-27 and MDA-MB-231. Synergistic antitumor activity was observed for both combined docetaxel and DXR, and docetaxel and THP against R-27 cells when contacted simultaneously. However, only additive effects were observed against MDA-MB-231 cells. Intracellular concentrations of DXR and THP in R-27 cells were significantly increased by docetaxel pretreatment, however, this increase was not observed in MDA-MB-231 cells, which exhibited only additive sensitivity to the treatment. Thus, docetaxel increased the antitumor activity of anthracyclines by increasing their intracellular concentrations.

Original language	English
Pages (from-to)	777-781
Number of pages	5
Journal	Oncology reports
Volume	9
Issue number	4
DOIs	https://doi.org/10.3892/or.9.4.777
Publication status	Published - 2002 Jul

Keywords

Breast cancer
Combination therapy
Docetaxel
Doxorubicin
Intracellular concentration
Synergism
Tetrahydropyranyladriamycin

ASJC Scopus subject areas

Oncology
Cancer Research

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Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation. / Egawa, Tomohisa; Kubota, Tetsuro; Suto, Akihiko; Otani, Yoshihide; Furukawa, Toshiharu; Watanabe, Masahiko; Kumai, Koichiro; Kitajima, Masaki.

In: Oncology reports, Vol. 9, No. 4, 07.2002, p. 777-781.

Research output: Contribution to journal › Article › peer-review

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abstract = "We assessed the combined antitumor activity of docetaxel and doxorubicin (DXR) and tetrahydropyranyladriamycin (THP) using the human breast carcinoma cell lines R-27 and MDA-MB-231. Synergistic antitumor activity was observed for both combined docetaxel and DXR, and docetaxel and THP against R-27 cells when contacted simultaneously. However, only additive effects were observed against MDA-MB-231 cells. Intracellular concentrations of DXR and THP in R-27 cells were significantly increased by docetaxel pretreatment, however, this increase was not observed in MDA-MB-231 cells, which exhibited only additive sensitivity to the treatment. Thus, docetaxel increased the antitumor activity of anthracyclines by increasing their intracellular concentrations.",

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AU - Egawa, Tomohisa

AU - Kubota, Tetsuro

AU - Suto, Akihiko

AU - Otani, Yoshihide

AU - Furukawa, Toshiharu

AU - Watanabe, Masahiko

AU - Kumai, Koichiro

AU - Kitajima, Masaki

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N2 - We assessed the combined antitumor activity of docetaxel and doxorubicin (DXR) and tetrahydropyranyladriamycin (THP) using the human breast carcinoma cell lines R-27 and MDA-MB-231. Synergistic antitumor activity was observed for both combined docetaxel and DXR, and docetaxel and THP against R-27 cells when contacted simultaneously. However, only additive effects were observed against MDA-MB-231 cells. Intracellular concentrations of DXR and THP in R-27 cells were significantly increased by docetaxel pretreatment, however, this increase was not observed in MDA-MB-231 cells, which exhibited only additive sensitivity to the treatment. Thus, docetaxel increased the antitumor activity of anthracyclines by increasing their intracellular concentrations.

AB - We assessed the combined antitumor activity of docetaxel and doxorubicin (DXR) and tetrahydropyranyladriamycin (THP) using the human breast carcinoma cell lines R-27 and MDA-MB-231. Synergistic antitumor activity was observed for both combined docetaxel and DXR, and docetaxel and THP against R-27 cells when contacted simultaneously. However, only additive effects were observed against MDA-MB-231 cells. Intracellular concentrations of DXR and THP in R-27 cells were significantly increased by docetaxel pretreatment, however, this increase was not observed in MDA-MB-231 cells, which exhibited only additive sensitivity to the treatment. Thus, docetaxel increased the antitumor activity of anthracyclines by increasing their intracellular concentrations.

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KW - Combination therapy

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Docetaxel enhances the cytotoxicity of anthracyclines by increasing intracellular drug accumulation

Abstract

Keywords

ASJC Scopus subject areas

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