Does completion thyroidectomy improve the outcome of patients with minimally invasive follicular carcinoma of the thyroid?

Kiminori Sugino, Kaori Kameyama, Mitsuji Nagahama, Wataru Kitagawa, Hiroshi Shibuya, Keiko Ohkuwa, Takashi Uruno, Junko Akaishi, Akifumi Suzuki, Chie Masaki, Ken Ichi Matsuzu, Michikazu Kawano, Koichi Ito

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background. The diagnosis of minimally invasive follicular thyroid carcinoma (MIFTC) is often made histologically after thyroid lobectomy. We attempted to determine whether completion thyroidectomy should be considered necessary for all patients diagnosed with MIFTC after thyroid lobectomy. Methods. The subjects of this study were a total of 324 patients who underwent thyroid lobectomy as initial surgery at our institution between 1989 and 2010 and diagnosed histologically as MIFTC. Completion thyroidectomy was performed on 101 patients, and the other 223 patients were followed up without further treatments. Cumulative cause-specific survival (CSS) rates and distant-metastasis-free survival (DMFS) rates were calculated by the Kaplan-Meier method. Differences between groups were analyzed for statistical significance by the log-rank test. Multivariate analysis was performed by using the Cox proportional hazards model. Results. During the follow-up period, 39 patients were diagnosed with distant metastasis, and 7 patients died of their disease. Age at the initial surgery was found to be a significant factor related to DMFS in both the univariate and multivariate analysis and to also be related to CSS in the univariate analysis. Completion thyroidectomy did not have a significant effect on DMFS or CSS according to the results of the univariate analysis, but it had significant effect on DMFS according to the results of the multivariate analysis. Conclusions. Although we were unable to demonstrate sufficient statistical evidence that completion thyroidectomy improved the outcome of MIFTC patients, it is noteworthy none of the patient who underwent completion thyroidectomy died of the disease.

Original languageEnglish
Pages (from-to)2981-2986
Number of pages6
JournalAnnals of Surgical Oncology
Volume21
Issue number9
DOIs
Publication statusPublished - 2014

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Follicular Adenocarcinoma
Thyroidectomy
Neoplasm Metastasis
Survival
Thyroid Gland
Multivariate Analysis
Survival Rate
Proportional Hazards Models

ASJC Scopus subject areas

  • Surgery
  • Oncology
  • Medicine(all)

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Does completion thyroidectomy improve the outcome of patients with minimally invasive follicular carcinoma of the thyroid? / Sugino, Kiminori; Kameyama, Kaori; Nagahama, Mitsuji; Kitagawa, Wataru; Shibuya, Hiroshi; Ohkuwa, Keiko; Uruno, Takashi; Akaishi, Junko; Suzuki, Akifumi; Masaki, Chie; Matsuzu, Ken Ichi; Kawano, Michikazu; Ito, Koichi.

In: Annals of Surgical Oncology, Vol. 21, No. 9, 2014, p. 2981-2986.

Research output: Contribution to journalArticle

Sugino, K, Kameyama, K, Nagahama, M, Kitagawa, W, Shibuya, H, Ohkuwa, K, Uruno, T, Akaishi, J, Suzuki, A, Masaki, C, Matsuzu, KI, Kawano, M & Ito, K 2014, 'Does completion thyroidectomy improve the outcome of patients with minimally invasive follicular carcinoma of the thyroid?', Annals of Surgical Oncology, vol. 21, no. 9, pp. 2981-2986. https://doi.org/10.1245/s10434-014-3734-2
Sugino, Kiminori ; Kameyama, Kaori ; Nagahama, Mitsuji ; Kitagawa, Wataru ; Shibuya, Hiroshi ; Ohkuwa, Keiko ; Uruno, Takashi ; Akaishi, Junko ; Suzuki, Akifumi ; Masaki, Chie ; Matsuzu, Ken Ichi ; Kawano, Michikazu ; Ito, Koichi. / Does completion thyroidectomy improve the outcome of patients with minimally invasive follicular carcinoma of the thyroid?. In: Annals of Surgical Oncology. 2014 ; Vol. 21, No. 9. pp. 2981-2986.
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AU - Kameyama, Kaori

AU - Nagahama, Mitsuji

AU - Kitagawa, Wataru

AU - Shibuya, Hiroshi

AU - Ohkuwa, Keiko

AU - Uruno, Takashi

AU - Akaishi, Junko

AU - Suzuki, Akifumi

AU - Masaki, Chie

AU - Matsuzu, Ken Ichi

AU - Kawano, Michikazu

AU - Ito, Koichi

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N2 - Background. The diagnosis of minimally invasive follicular thyroid carcinoma (MIFTC) is often made histologically after thyroid lobectomy. We attempted to determine whether completion thyroidectomy should be considered necessary for all patients diagnosed with MIFTC after thyroid lobectomy. Methods. The subjects of this study were a total of 324 patients who underwent thyroid lobectomy as initial surgery at our institution between 1989 and 2010 and diagnosed histologically as MIFTC. Completion thyroidectomy was performed on 101 patients, and the other 223 patients were followed up without further treatments. Cumulative cause-specific survival (CSS) rates and distant-metastasis-free survival (DMFS) rates were calculated by the Kaplan-Meier method. Differences between groups were analyzed for statistical significance by the log-rank test. Multivariate analysis was performed by using the Cox proportional hazards model. Results. During the follow-up period, 39 patients were diagnosed with distant metastasis, and 7 patients died of their disease. Age at the initial surgery was found to be a significant factor related to DMFS in both the univariate and multivariate analysis and to also be related to CSS in the univariate analysis. Completion thyroidectomy did not have a significant effect on DMFS or CSS according to the results of the univariate analysis, but it had significant effect on DMFS according to the results of the multivariate analysis. Conclusions. Although we were unable to demonstrate sufficient statistical evidence that completion thyroidectomy improved the outcome of MIFTC patients, it is noteworthy none of the patient who underwent completion thyroidectomy died of the disease.

AB - Background. The diagnosis of minimally invasive follicular thyroid carcinoma (MIFTC) is often made histologically after thyroid lobectomy. We attempted to determine whether completion thyroidectomy should be considered necessary for all patients diagnosed with MIFTC after thyroid lobectomy. Methods. The subjects of this study were a total of 324 patients who underwent thyroid lobectomy as initial surgery at our institution between 1989 and 2010 and diagnosed histologically as MIFTC. Completion thyroidectomy was performed on 101 patients, and the other 223 patients were followed up without further treatments. Cumulative cause-specific survival (CSS) rates and distant-metastasis-free survival (DMFS) rates were calculated by the Kaplan-Meier method. Differences between groups were analyzed for statistical significance by the log-rank test. Multivariate analysis was performed by using the Cox proportional hazards model. Results. During the follow-up period, 39 patients were diagnosed with distant metastasis, and 7 patients died of their disease. Age at the initial surgery was found to be a significant factor related to DMFS in both the univariate and multivariate analysis and to also be related to CSS in the univariate analysis. Completion thyroidectomy did not have a significant effect on DMFS or CSS according to the results of the univariate analysis, but it had significant effect on DMFS according to the results of the multivariate analysis. Conclusions. Although we were unable to demonstrate sufficient statistical evidence that completion thyroidectomy improved the outcome of MIFTC patients, it is noteworthy none of the patient who underwent completion thyroidectomy died of the disease.

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