Does the Intestinal Microbiota Explain Differences in the Epidemiology of Liver Disease between East and West?

Nobuhiro Nakamoto, Bernd Schnabl

Research output: Contribution to journalReview articlepeer-review

Abstract

Changes in bacterial communities are associated with the pathogenesis of many diseases including inflammatory bowel disease and liver disease. Dysbiosis can induce intestinal inflammation resulting in increased intestinal permeability and bacterial translocation. The majority of chronic liver diseases are associated with bacterial translocation resulting in or enhancing an inflammatory response in the liver. Intestinal inflammation and a dysfunctional intestinal barrier are not sufficient to cause liver disease in the absence of an additional liver insult. In this article, the authors summarize differences in intestinal microbiota composition between Eastern and Western countries. The authors specifically discuss whether differences in microbiota composition could explain the epidemiological differences in liver disease found in Asia and Europe/the USA.

Original languageEnglish
Pages (from-to)3-8
Number of pages6
JournalInflammatory Intestinal Diseases
Volume1
Issue number1
DOIs
Publication statusPublished - 2016 Apr 1

Keywords

  • East and West
  • Inflammatory bowel disease
  • Liver disease
  • Microbiota
  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis

ASJC Scopus subject areas

  • Gastroenterology

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