Dolabelides C and D, cytotoxic macrolides isolated from the sea hare Dolabella auricularia

Kiyotake Suenaga, Tomohiro Nagoya, Takunobu Shibata, Hideo Kigoshi, Kiyoyuki Yamada

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Two new cytotoxic 24-membered macrolides, dolabelides C and D, were isolated from the Japanese sea hare Dolabella auricularia. Their gross structures were deduced by spectroscopic analysis including the 2D NMR technique, and their absolute stereochemistry was determined by means of chemical correlation with the known dolabelide A. Dolabelides C and D exhibited cytotoxicities against HeLa S3 cells with IC50 values of 1.9 and 1.5 μg/mL, respectively.

Original languageEnglish
Pages (from-to)155-157
Number of pages3
JournalJournal of Natural Products
Volume60
Issue number2
DOIs
Publication statusPublished - 1997
Externally publishedYes

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macrolides
Stereochemistry
Spectroscopic analysis
Macrolides
stereochemistry
Cytotoxicity
HeLa Cells
Oceans and Seas
Inhibitory Concentration 50
inhibitory concentration 50
cytotoxicity
Nuclear magnetic resonance
cells
methodology
dolabelide A
Dolabella auricularia
Anaspidea

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Dolabelides C and D, cytotoxic macrolides isolated from the sea hare Dolabella auricularia. / Suenaga, Kiyotake; Nagoya, Tomohiro; Shibata, Takunobu; Kigoshi, Hideo; Yamada, Kiyoyuki.

In: Journal of Natural Products, Vol. 60, No. 2, 1997, p. 155-157.

Research output: Contribution to journalArticle

Suenaga, Kiyotake ; Nagoya, Tomohiro ; Shibata, Takunobu ; Kigoshi, Hideo ; Yamada, Kiyoyuki. / Dolabelides C and D, cytotoxic macrolides isolated from the sea hare Dolabella auricularia. In: Journal of Natural Products. 1997 ; Vol. 60, No. 2. pp. 155-157.
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