Dolabelides C and D, cytotoxic macrolides isolated from the sea hare Dolabella auricularia

Kiyotake Suenaga; Tomohiro Nagoya; Takunobu Shibata; Hideo Kigoshi; Kiyoyuki Yamada

doi:10.1021/np960612q

Dolabelides C and D, cytotoxic macrolides isolated from the sea hare Dolabella auricularia

Kiyotake Suenaga, Tomohiro Nagoya, Takunobu Shibata, Hideo Kigoshi, Kiyoyuki Yamada

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Two new cytotoxic 24-membered macrolides, dolabelides C and D, were isolated from the Japanese sea hare Dolabella auricularia. Their gross structures were deduced by spectroscopic analysis including the 2D NMR technique, and their absolute stereochemistry was determined by means of chemical correlation with the known dolabelide A. Dolabelides C and D exhibited cytotoxicities against HeLa S₃ cells with IC₅₀ values of 1.9 and 1.5 μg/mL, respectively.

Original language	English
Pages (from-to)	155-157
Number of pages	3
Journal	Journal of Natural Products
Volume	60
Issue number	2
DOIs	https://doi.org/10.1021/np960612q
Publication status	Published - 1997 Jan 1
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np960612q

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AU - Shibata, Takunobu

AU - Kigoshi, Hideo

AU - Yamada, Kiyoyuki

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Dolabelides C and D, cytotoxic macrolides isolated from the sea hare Dolabella auricularia

Abstract

ASJC Scopus subject areas

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