Dolabelides C and D, cytotoxic macrolides isolated from the sea hare Dolabella auricularia

Kiyotake Suenaga, Tomohiro Nagoya, Takunobu Shibata, Hideo Kigoshi, Kiyoyuki Yamada

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Two new cytotoxic 24-membered macrolides, dolabelides C and D, were isolated from the Japanese sea hare Dolabella auricularia. Their gross structures were deduced by spectroscopic analysis including the 2D NMR technique, and their absolute stereochemistry was determined by means of chemical correlation with the known dolabelide A. Dolabelides C and D exhibited cytotoxicities against HeLa S3 cells with IC50 values of 1.9 and 1.5 μg/mL, respectively.

Original languageEnglish
Pages (from-to)155-157
Number of pages3
JournalJournal of Natural Products
Volume60
Issue number2
DOIs
Publication statusPublished - 1997 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Dolabelides C and D, cytotoxic macrolides isolated from the sea hare Dolabella auricularia'. Together they form a unique fingerprint.

  • Cite this