Donor-recipient gender difference affects severity of dry eye after hematopoietic stem cell transplantation

M. Kamoi, Y. Ogawa, M. Uchino, Y. Tatematsu, Takehiko Mori, Shinichiro Okamoto, Kazuo Tsubota

Research output: Contribution to journalArticle

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Abstract

Purpose To determine whether the incidence rate and severity of dry eye after hematopoietic stem cell transplantation varies with donor vsrecipient gender. Methods We limited this study to patients received bone marrow transplantation (BMT). In all, 172 patients received BMT at Keio University School of Medicine between January 2000 and May 2007. Of them, 136 recipients who survived at least 70 days were studied prospectively. We classified the 136 patients according to the gender of the donor and the recipient (group I: female to female; group II: male to male; group III: male to female; group IV: female to male). The incidence and severity of chronic graft-vs-host disease-associated dry eye were determined for each group. The donor gender was masked when we assessed dry eye and calculate the incidence. Results The incidence of dry eye was 47.4% for group I, 37.5% for group II, 58.6% for group III, and 42.9% for group IV. The percentage of patients with severe dry eye was 44.4, 50.0, 35.3, and 77.8% respectively. There was a significant difference between the percent severe dry eye/total dry eye incidences in groups III and IV (P=0.0375) (odds ratio, 7.6; 95% confidence interval, 1.00-101.01).Conclusions Close attention must be paid to the development of dry eye in cases of female to male BMTs, because the ratio of severe/total dry eye is more common in cases of female to male BMTs than in other gender combination.

Original languageEnglish
Pages (from-to)860-865
Number of pages6
JournalEye
Volume25
Issue number7
DOIs
Publication statusPublished - 2011 Jul

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Hematopoietic Stem Cell Transplantation
Tissue Donors
Incidence
Bone Marrow Transplantation
Graft vs Host Disease
Odds Ratio
Medicine
Confidence Intervals

Keywords

  • allogeneic hematopoietic stem cell transplantation
  • chronic graft-vs-host disease
  • dry eye
  • gender-mismatched transplantation
  • minor histocompatibility antigens

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Donor-recipient gender difference affects severity of dry eye after hematopoietic stem cell transplantation. / Kamoi, M.; Ogawa, Y.; Uchino, M.; Tatematsu, Y.; Mori, Takehiko; Okamoto, Shinichiro; Tsubota, Kazuo.

In: Eye, Vol. 25, No. 7, 07.2011, p. 860-865.

Research output: Contribution to journalArticle

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abstract = "Purpose To determine whether the incidence rate and severity of dry eye after hematopoietic stem cell transplantation varies with donor vsrecipient gender. Methods We limited this study to patients received bone marrow transplantation (BMT). In all, 172 patients received BMT at Keio University School of Medicine between January 2000 and May 2007. Of them, 136 recipients who survived at least 70 days were studied prospectively. We classified the 136 patients according to the gender of the donor and the recipient (group I: female to female; group II: male to male; group III: male to female; group IV: female to male). The incidence and severity of chronic graft-vs-host disease-associated dry eye were determined for each group. The donor gender was masked when we assessed dry eye and calculate the incidence. Results The incidence of dry eye was 47.4{\%} for group I, 37.5{\%} for group II, 58.6{\%} for group III, and 42.9{\%} for group IV. The percentage of patients with severe dry eye was 44.4, 50.0, 35.3, and 77.8{\%} respectively. There was a significant difference between the percent severe dry eye/total dry eye incidences in groups III and IV (P=0.0375) (odds ratio, 7.6; 95{\%} confidence interval, 1.00-101.01).Conclusions Close attention must be paid to the development of dry eye in cases of female to male BMTs, because the ratio of severe/total dry eye is more common in cases of female to male BMTs than in other gender combination.",
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N2 - Purpose To determine whether the incidence rate and severity of dry eye after hematopoietic stem cell transplantation varies with donor vsrecipient gender. Methods We limited this study to patients received bone marrow transplantation (BMT). In all, 172 patients received BMT at Keio University School of Medicine between January 2000 and May 2007. Of them, 136 recipients who survived at least 70 days were studied prospectively. We classified the 136 patients according to the gender of the donor and the recipient (group I: female to female; group II: male to male; group III: male to female; group IV: female to male). The incidence and severity of chronic graft-vs-host disease-associated dry eye were determined for each group. The donor gender was masked when we assessed dry eye and calculate the incidence. Results The incidence of dry eye was 47.4% for group I, 37.5% for group II, 58.6% for group III, and 42.9% for group IV. The percentage of patients with severe dry eye was 44.4, 50.0, 35.3, and 77.8% respectively. There was a significant difference between the percent severe dry eye/total dry eye incidences in groups III and IV (P=0.0375) (odds ratio, 7.6; 95% confidence interval, 1.00-101.01).Conclusions Close attention must be paid to the development of dry eye in cases of female to male BMTs, because the ratio of severe/total dry eye is more common in cases of female to male BMTs than in other gender combination.

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