Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders

Hiroshi Manki, Shigenobu Kanba, Taro Muramatsu, Susumu Higuchi, Eiji Suzuki, Sachio Matsushita, Yutaka Ono, Hiromi Chiba, Futoshi Shintani, Makoto Nakamura, Gohei Yagi, Masahiro Asai

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)


Disturbances in dopaminergic systems have been implicated in the etiology of mood disorders. Although genetic factors also play an important role, no major gene has been identified. We conducted an association study using the dopamine D2, D3 and D4 receptor, and transporter gene polymorphisms, comparing 101 mood-disorder patients (52 bipolar and 49 unipolar) and 100 controls. Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. Further investigations are needed to clarify the clinical significance of this association in the pathophysiology of mood disorders.

Original languageEnglish
Pages (from-to)7-13
Number of pages7
JournalJournal of Affective Disorders
Issue number1-2
Publication statusPublished - 1996 Sept 9
Externally publishedYes


  • Bipolar disorder
  • Dopamine receptor
  • Dopamine transporter
  • Major depression
  • Mood disorder
  • Polymorphism

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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