TY - JOUR
T1 - Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders
AU - Manki, Hiroshi
AU - Kanba, Shigenobu
AU - Muramatsu, Taro
AU - Higuchi, Susumu
AU - Suzuki, Eiji
AU - Matsushita, Sachio
AU - Ono, Yutaka
AU - Chiba, Hiromi
AU - Shintani, Futoshi
AU - Nakamura, Makoto
AU - Yagi, Gohei
AU - Asai, Masahiro
N1 - Funding Information:
We are grateful to Y. Kabeshima for contributing patients to this study, which was supported by research grants from Ohme Keiyu Hospital (Director N. Otsuka), Inokashira Hospital, and the Japanese Ministry of Health and Welfare.
PY - 1996/9/9
Y1 - 1996/9/9
N2 - Disturbances in dopaminergic systems have been implicated in the etiology of mood disorders. Although genetic factors also play an important role, no major gene has been identified. We conducted an association study using the dopamine D2, D3 and D4 receptor, and transporter gene polymorphisms, comparing 101 mood-disorder patients (52 bipolar and 49 unipolar) and 100 controls. Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. Further investigations are needed to clarify the clinical significance of this association in the pathophysiology of mood disorders.
AB - Disturbances in dopaminergic systems have been implicated in the etiology of mood disorders. Although genetic factors also play an important role, no major gene has been identified. We conducted an association study using the dopamine D2, D3 and D4 receptor, and transporter gene polymorphisms, comparing 101 mood-disorder patients (52 bipolar and 49 unipolar) and 100 controls. Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. Further investigations are needed to clarify the clinical significance of this association in the pathophysiology of mood disorders.
KW - Bipolar disorder
KW - Dopamine receptor
KW - Dopamine transporter
KW - Major depression
KW - Mood disorder
KW - Polymorphism
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U2 - 10.1016/0165-0327(96)00035-3
DO - 10.1016/0165-0327(96)00035-3
M3 - Article
C2 - 8882909
AN - SCOPUS:0030576998
SN - 0165-0327
VL - 40
SP - 7
EP - 13
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 1-2
ER -
