Dopamine D2/3 receptor availability in the striatum of antipsychotic-free older patients with schizophrenia-A [11C]-raclopride PET study

Shinichiro Nakajima, Fernando Caravaggio, David C. Mamo, Benoit H. Mulsant, Jun Ku Chung, Eric Plitman, Yusuke Iwata, Philip Gerretsen, Hiroyuki Uchida, Takefumi Suzuki, Wanna Mar, Alan A. Wilson, Sylvain Houle, Ariel Graff-Guerrero

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11 Citations (Scopus)

Abstract

Background: No study has examined dopamine D2/3 receptor (D2/3R) availability in antipsychotic-free older patients with schizophrenia. Methods: We included patients with schizophrenia 50years or older who were antipsychotic-free for at least 3months. We compared non-displaceable binding potential (BPND) of [11C]-raclopride in the caudate, putamen, ventral striatum, and globus pallidus between patients and age- and sex-matched healthy controls. Results: Ten patients participated (antipsychotic-naive=4). No differences in BPND were found between patients and controls in any ROIs (F(1, 72)=42, p=52). Conclusion: The preliminary results suggest no differences in D2/3R availability between antipsychotic-free older patients with schizophrenia and controls.

Original languageEnglish
Pages (from-to)263-267
Number of pages5
JournalSchizophrenia Research
Volume164
Issue number1-3
DOIs
Publication statusPublished - 2015 May 1

Keywords

  • Aging
  • D receptor
  • Dopamine
  • PET
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Nakajima, S., Caravaggio, F., Mamo, D. C., Mulsant, B. H., Chung, J. K., Plitman, E., Iwata, Y., Gerretsen, P., Uchida, H., Suzuki, T., Mar, W., Wilson, A. A., Houle, S., & Graff-Guerrero, A. (2015). Dopamine D2/3 receptor availability in the striatum of antipsychotic-free older patients with schizophrenia-A [11C]-raclopride PET study. Schizophrenia Research, 164(1-3), 263-267. https://doi.org/10.1016/j.schres.2015.02.020