Dopamine Transporter Gene Polymorphism and Alcoholism

Taro Muramatsu, S. Higuchi

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

In this search for a possible association between the dopamine transporter gene (DAT1) polymorphism and alcoholism, 655 Japanese alcoholics were grouped according to their aldehyde dehydrogenase-2 (ALDH2) genotypes. Because inactive ALDH2 is an established negative risk factor for alcoholism, alcoholics with the mutant allele, ALDH2*2, were considered a relatively homogeneous group. The frequency of the 7-repeat allele of the DAT1 variable number of tandem repeat was significantly higher in alcoholics with ALDH2*2 than in control subjects. These results are consistent with the hypothesis that alteration in the dopaminergic system plays some role in the development of alcoholism.

Original languageEnglish
Pages (from-to)28-32
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume211
Issue number1
DOIs
Publication statusPublished - 1995 Jun 6
Externally publishedYes

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Aldehyde Dehydrogenase
Dopamine Plasma Membrane Transport Proteins
Polymorphism
Alcoholism
Alcoholics
Genes
Alleles
Minisatellite Repeats
Genotype

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Biophysics
  • Biochemistry

Cite this

Dopamine Transporter Gene Polymorphism and Alcoholism. / Muramatsu, Taro; Higuchi, S.

In: Biochemical and Biophysical Research Communications, Vol. 211, No. 1, 06.06.1995, p. 28-32.

Research output: Contribution to journalArticle

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