Dopamine Transporter Gene Polymorphism and Psychiatric Symptoms Seen in Schizophrenic Patients at Their First Episode

Toshiya Inada, Tetsuyoshi Sugita, Izumi Dobashi, Ataru Inagaki, Yoshie Kitao, Genichi Matsuda, Shingo Kato, Toshiya Takano, Gohei Yagi, Masahiro Asai

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To investigate the possible role of the dopamine transporter (DAT) gene in determining the phenotype in human subjects, allele frequencies for the 40-bp variable number of tandem repeats (VNTR) polymorphism at this site were compared between 117 Japanese normal controls and 118 schizophrenic patients, including six subgroups: early-onset, those with a family history, and those suffering from one of the following psychiatric symptoms at their first episode: delusion and hallucination; disorganization; bizarre behavior; and negative symptoms. No significant differences were observed between the group as a whole or any subgroup of schizophrenic patients and controls. The results indicate that VNTR polymorphism in the DAT gene is unlikely to be a major contributor to any of the psychiatric parameters examined in the present population of schizophrenic subjects.

Original languageEnglish
Pages (from-to)406-408
Number of pages3
JournalAmerican Journal of Medical Genetics - Seminars in Medical Genetics
Issue number4
Publication statusPublished - 1996 Jul 26



  • Bizarre behavior
  • Delusion
  • Disorganization
  • Hallucination
  • Negative symptoms

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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