TY - JOUR
T1 - Dopamine Transporter Gene Polymorphism and Psychiatric Symptoms Seen in Schizophrenic Patients at Their First Episode
AU - Inada, Toshiya
AU - Sugita, Tetsuyoshi
AU - Dobashi, Izumi
AU - Inagaki, Ataru
AU - Kitao, Yoshie
AU - Matsuda, Genichi
AU - Kato, Shingo
AU - Takano, Toshiya
AU - Yagi, Gohei
AU - Asai, Masahiro
PY - 1996/7/26
Y1 - 1996/7/26
N2 - To investigate the possible role of the dopamine transporter (DAT) gene in determining the phenotype in human subjects, allele frequencies for the 40-bp variable number of tandem repeats (VNTR) polymorphism at this site were compared between 117 Japanese normal controls and 118 schizophrenic patients, including six subgroups: early-onset, those with a family history, and those suffering from one of the following psychiatric symptoms at their first episode: delusion and hallucination; disorganization; bizarre behavior; and negative symptoms. No significant differences were observed between the group as a whole or any subgroup of schizophrenic patients and controls. The results indicate that VNTR polymorphism in the DAT gene is unlikely to be a major contributor to any of the psychiatric parameters examined in the present population of schizophrenic subjects.
AB - To investigate the possible role of the dopamine transporter (DAT) gene in determining the phenotype in human subjects, allele frequencies for the 40-bp variable number of tandem repeats (VNTR) polymorphism at this site were compared between 117 Japanese normal controls and 118 schizophrenic patients, including six subgroups: early-onset, those with a family history, and those suffering from one of the following psychiatric symptoms at their first episode: delusion and hallucination; disorganization; bizarre behavior; and negative symptoms. No significant differences were observed between the group as a whole or any subgroup of schizophrenic patients and controls. The results indicate that VNTR polymorphism in the DAT gene is unlikely to be a major contributor to any of the psychiatric parameters examined in the present population of schizophrenic subjects.
KW - Bizarre behavior
KW - Delusion
KW - Disorganization
KW - Hallucination
KW - Negative symptoms
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U2 - 10.1002/(SICI)1096-8628(19960726)67:4<406::AID-AJMG15>3.0.CO;2-N
DO - 10.1002/(SICI)1096-8628(19960726)67:4<406::AID-AJMG15>3.0.CO;2-N
M3 - Article
C2 - 8837710
AN - SCOPUS:0029835642
SN - 1552-4868
VL - 67
SP - 406
EP - 408
JO - American Journal of Medical Genetics, Part C: Seminars in Medical Genetics
JF - American Journal of Medical Genetics, Part C: Seminars in Medical Genetics
IS - 4
ER -