Dose volume histogram analysis of focal liver reaction in follow-up multiphasic CT following stereotactic body radiotherapy for small hepatocellular carcinoma

Atsuya Takeda, Yohei Oku, Naoko Sanuki, Etsuo Kunieda, Naoyoshi Koike, Yousuke Aoki, Toshio Ohashi, Shogo Iwabuchi, Kentaro Takatsuka, Toshiaki Takeda, Akitomo Sugawara

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose: To investigate threshold dose (TD) of focal liver reaction (FLR) following stereotactic body radiotherapy (SBRT) for patients with hepatocellular carcinoma (HCC) and liver cirrhosis. Materials and methods: In consecutive 50 patients receiving SBRT for small HCC, 38 patients receiving SBRT and follow up >6 months, FLR on follow-up CT had been previously studied. Patients with good concordance between FLR and highly irradiated area were eligible. Dose volume histogram (DVH) was used to identify TDs for FLR. Clinical factors were analyzed for correlation with TDs. Results: Of 24 eligible patients, 23 had Child-Pugh score A and 1 scored B. Presence of FLR peaked at a median of 6 (range; 3-12) months. The median and 95% confidential intervals of TDs of pre-contrast and portal-venous phase CT were 32.4 Gy (30.3-35.4) and 34.4 Gy (31.9-36.0), respectively. Each median coefficient representing the concordance was 74.9% (range; 55.8-98.0%) and 80.5% (range; 70.8-92.4%), respectively. No clinical factors significantly correlated with the TDs. Conclusion: We proposed 30 Gy/5 fractions as TD of FLRs following SBRT for patients with HCC and liver cirrhosis. This TD will enable us to predict injured liver volume and to avoid complication beforehand from toxicity. Further pathological and clinical studies, in addition to more practical and precise data of DVH, are needed to clarify the significance of FLRs.

Original languageEnglish
Pages (from-to)374-378
Number of pages5
JournalRadiotherapy and Oncology
Volume104
Issue number3
DOIs
Publication statusPublished - 2012 Sep

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Radiosurgery
Hepatocellular Carcinoma
Liver
Liver Cirrhosis

Keywords

  • Dose volume histogram
  • Focal liver reaction
  • Hepatocellular carcinoma
  • Liver toxicity
  • Stereotactic body radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

Cite this

Dose volume histogram analysis of focal liver reaction in follow-up multiphasic CT following stereotactic body radiotherapy for small hepatocellular carcinoma. / Takeda, Atsuya; Oku, Yohei; Sanuki, Naoko; Kunieda, Etsuo; Koike, Naoyoshi; Aoki, Yousuke; Ohashi, Toshio; Iwabuchi, Shogo; Takatsuka, Kentaro; Takeda, Toshiaki; Sugawara, Akitomo.

In: Radiotherapy and Oncology, Vol. 104, No. 3, 09.2012, p. 374-378.

Research output: Contribution to journalArticle

Takeda, Atsuya ; Oku, Yohei ; Sanuki, Naoko ; Kunieda, Etsuo ; Koike, Naoyoshi ; Aoki, Yousuke ; Ohashi, Toshio ; Iwabuchi, Shogo ; Takatsuka, Kentaro ; Takeda, Toshiaki ; Sugawara, Akitomo. / Dose volume histogram analysis of focal liver reaction in follow-up multiphasic CT following stereotactic body radiotherapy for small hepatocellular carcinoma. In: Radiotherapy and Oncology. 2012 ; Vol. 104, No. 3. pp. 374-378.
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abstract = "Purpose: To investigate threshold dose (TD) of focal liver reaction (FLR) following stereotactic body radiotherapy (SBRT) for patients with hepatocellular carcinoma (HCC) and liver cirrhosis. Materials and methods: In consecutive 50 patients receiving SBRT for small HCC, 38 patients receiving SBRT and follow up >6 months, FLR on follow-up CT had been previously studied. Patients with good concordance between FLR and highly irradiated area were eligible. Dose volume histogram (DVH) was used to identify TDs for FLR. Clinical factors were analyzed for correlation with TDs. Results: Of 24 eligible patients, 23 had Child-Pugh score A and 1 scored B. Presence of FLR peaked at a median of 6 (range; 3-12) months. The median and 95{\%} confidential intervals of TDs of pre-contrast and portal-venous phase CT were 32.4 Gy (30.3-35.4) and 34.4 Gy (31.9-36.0), respectively. Each median coefficient representing the concordance was 74.9{\%} (range; 55.8-98.0{\%}) and 80.5{\%} (range; 70.8-92.4{\%}), respectively. No clinical factors significantly correlated with the TDs. Conclusion: We proposed 30 Gy/5 fractions as TD of FLRs following SBRT for patients with HCC and liver cirrhosis. This TD will enable us to predict injured liver volume and to avoid complication beforehand from toxicity. Further pathological and clinical studies, in addition to more practical and precise data of DVH, are needed to clarify the significance of FLRs.",
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AU - Koike, Naoyoshi

AU - Aoki, Yousuke

AU - Ohashi, Toshio

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AU - Takeda, Toshiaki

AU - Sugawara, Akitomo

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AB - Purpose: To investigate threshold dose (TD) of focal liver reaction (FLR) following stereotactic body radiotherapy (SBRT) for patients with hepatocellular carcinoma (HCC) and liver cirrhosis. Materials and methods: In consecutive 50 patients receiving SBRT for small HCC, 38 patients receiving SBRT and follow up >6 months, FLR on follow-up CT had been previously studied. Patients with good concordance between FLR and highly irradiated area were eligible. Dose volume histogram (DVH) was used to identify TDs for FLR. Clinical factors were analyzed for correlation with TDs. Results: Of 24 eligible patients, 23 had Child-Pugh score A and 1 scored B. Presence of FLR peaked at a median of 6 (range; 3-12) months. The median and 95% confidential intervals of TDs of pre-contrast and portal-venous phase CT were 32.4 Gy (30.3-35.4) and 34.4 Gy (31.9-36.0), respectively. Each median coefficient representing the concordance was 74.9% (range; 55.8-98.0%) and 80.5% (range; 70.8-92.4%), respectively. No clinical factors significantly correlated with the TDs. Conclusion: We proposed 30 Gy/5 fractions as TD of FLRs following SBRT for patients with HCC and liver cirrhosis. This TD will enable us to predict injured liver volume and to avoid complication beforehand from toxicity. Further pathological and clinical studies, in addition to more practical and precise data of DVH, are needed to clarify the significance of FLRs.

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