Double-layer collagen microtube for perfusable heterogeneous culture

Shun Itai, Hiroaki Onoe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a double-layer collagen microtube device for in vitro perfusable multilayered 3D cell culture. Thicknesses of the collagen layers in the microtube can flexibly designed, and heterogeneous types of cells can be co-cultured in each collagen layer or surfaces. Moreover, while our collagen tube is directly attached to silicone tubes, the collagen microtube can be easily connected to an external pump system for perfusion culture. We believe that our device could help easy fabrication of various tissue models mimicking in vivo, especially blood vessel models or vascularized skin models, and contribute to the development of pharmacokinetic testing platforms and regenerative medicine.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages1137-1138
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2020 Jan 1
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: 2017 Oct 222017 Oct 26

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period17/10/2217/10/26

Keywords

  • 3D Tissue Engineering
  • Co-Culture
  • Collagen
  • Vascularize

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Itai, S., & Onoe, H. (2020). Double-layer collagen microtube for perfusable heterogeneous culture. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1137-1138). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.