Double-phase helical CT of small renal parenchymal neoplasms: Correlation with pathologic findings and tumor angiogenesis

Masahiro Jinzaki, Akihiro Tanimoto, Makio Mukai, Eiji Ikeda, Seiji Kobayashi, Yuji Yuasa, Yoshiaki Narimatsu, Masaru Murai

Research output: Contribution to journalArticle

250 Citations (Scopus)

Abstract

Purpose: To correlate the enhancement pattern of double-phase helical computed tomography (CT) of small renal parenchymal neoplasms with pathologic findings and tumor angiogenesis, and evaluate whether the enhancement pattern would be useful in differentiating the histomorphologic types of small renal parenchymal neoplasms. Materials and Methods: Double-phase helical CT (5 mm slice) of the cortico-medullary phase (CMP) and late nephrographic phase (NP) was performed in 40 surgically resected renal neoplasms <3.5 cm. The patterns of CT attenuation value and homogeneity were correlated with the subtypes of neoplasms, microvessel density, and the existence of intratumoral necrosis or hemorrhage. Results: Clear cell renal cell carcinomas (RCC) (n = 29) showed a peak attenuation value in the CMP of >100 HU [Hounsfield units]. Chromophobe cell RCC (n = 2) showed a peak attenuation value in the CMP of <100 HU. Papillary RCC (n = 5) showed a gradual enhancement with the attenuation value in the CMP of <100 HU. However oncocytomas (n = 2) and metanephric adenomas (n = 2) also showed patterns similar to these subtypes of RCC. The degree of enhancement in the CMP correlated with microvessel density (r = 0.87). All tumors with an homogeneous enhancement pattern did not show necrosis or hemorrhage on histologic specimen. Conclusion: The enhancement pattern in double-phase helical CT was different among the subtypes of RCC, and correlated with microvessel density or the existence of intratumoral necrosis or hemorrhage. However it did not differentiate between RCC and other solid tumors.

Original languageEnglish
Pages (from-to)835-842
Number of pages8
JournalJournal of Computer Assisted Tomography
Volume24
Issue number6
DOIs
Publication statusPublished - 2000

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Kidney Neoplasms
Spiral Computed Tomography
Microvessels
Necrosis
Hemorrhage
Oxyphilic Adenoma
Neoplasms
Adenoma

Keywords

  • Computed tomography, helical
  • Kidneys, abnormalities
  • Kidneys, neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Double-phase helical CT of small renal parenchymal neoplasms : Correlation with pathologic findings and tumor angiogenesis. / Jinzaki, Masahiro; Tanimoto, Akihiro; Mukai, Makio; Ikeda, Eiji; Kobayashi, Seiji; Yuasa, Yuji; Narimatsu, Yoshiaki; Murai, Masaru.

In: Journal of Computer Assisted Tomography, Vol. 24, No. 6, 2000, p. 835-842.

Research output: Contribution to journalArticle

Jinzaki, Masahiro ; Tanimoto, Akihiro ; Mukai, Makio ; Ikeda, Eiji ; Kobayashi, Seiji ; Yuasa, Yuji ; Narimatsu, Yoshiaki ; Murai, Masaru. / Double-phase helical CT of small renal parenchymal neoplasms : Correlation with pathologic findings and tumor angiogenesis. In: Journal of Computer Assisted Tomography. 2000 ; Vol. 24, No. 6. pp. 835-842.
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abstract = "Purpose: To correlate the enhancement pattern of double-phase helical computed tomography (CT) of small renal parenchymal neoplasms with pathologic findings and tumor angiogenesis, and evaluate whether the enhancement pattern would be useful in differentiating the histomorphologic types of small renal parenchymal neoplasms. Materials and Methods: Double-phase helical CT (5 mm slice) of the cortico-medullary phase (CMP) and late nephrographic phase (NP) was performed in 40 surgically resected renal neoplasms <3.5 cm. The patterns of CT attenuation value and homogeneity were correlated with the subtypes of neoplasms, microvessel density, and the existence of intratumoral necrosis or hemorrhage. Results: Clear cell renal cell carcinomas (RCC) (n = 29) showed a peak attenuation value in the CMP of >100 HU [Hounsfield units]. Chromophobe cell RCC (n = 2) showed a peak attenuation value in the CMP of <100 HU. Papillary RCC (n = 5) showed a gradual enhancement with the attenuation value in the CMP of <100 HU. However oncocytomas (n = 2) and metanephric adenomas (n = 2) also showed patterns similar to these subtypes of RCC. The degree of enhancement in the CMP correlated with microvessel density (r = 0.87). All tumors with an homogeneous enhancement pattern did not show necrosis or hemorrhage on histologic specimen. Conclusion: The enhancement pattern in double-phase helical CT was different among the subtypes of RCC, and correlated with microvessel density or the existence of intratumoral necrosis or hemorrhage. However it did not differentiate between RCC and other solid tumors.",
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T1 - Double-phase helical CT of small renal parenchymal neoplasms

T2 - Correlation with pathologic findings and tumor angiogenesis

AU - Jinzaki, Masahiro

AU - Tanimoto, Akihiro

AU - Mukai, Makio

AU - Ikeda, Eiji

AU - Kobayashi, Seiji

AU - Yuasa, Yuji

AU - Narimatsu, Yoshiaki

AU - Murai, Masaru

PY - 2000

Y1 - 2000

N2 - Purpose: To correlate the enhancement pattern of double-phase helical computed tomography (CT) of small renal parenchymal neoplasms with pathologic findings and tumor angiogenesis, and evaluate whether the enhancement pattern would be useful in differentiating the histomorphologic types of small renal parenchymal neoplasms. Materials and Methods: Double-phase helical CT (5 mm slice) of the cortico-medullary phase (CMP) and late nephrographic phase (NP) was performed in 40 surgically resected renal neoplasms <3.5 cm. The patterns of CT attenuation value and homogeneity were correlated with the subtypes of neoplasms, microvessel density, and the existence of intratumoral necrosis or hemorrhage. Results: Clear cell renal cell carcinomas (RCC) (n = 29) showed a peak attenuation value in the CMP of >100 HU [Hounsfield units]. Chromophobe cell RCC (n = 2) showed a peak attenuation value in the CMP of <100 HU. Papillary RCC (n = 5) showed a gradual enhancement with the attenuation value in the CMP of <100 HU. However oncocytomas (n = 2) and metanephric adenomas (n = 2) also showed patterns similar to these subtypes of RCC. The degree of enhancement in the CMP correlated with microvessel density (r = 0.87). All tumors with an homogeneous enhancement pattern did not show necrosis or hemorrhage on histologic specimen. Conclusion: The enhancement pattern in double-phase helical CT was different among the subtypes of RCC, and correlated with microvessel density or the existence of intratumoral necrosis or hemorrhage. However it did not differentiate between RCC and other solid tumors.

AB - Purpose: To correlate the enhancement pattern of double-phase helical computed tomography (CT) of small renal parenchymal neoplasms with pathologic findings and tumor angiogenesis, and evaluate whether the enhancement pattern would be useful in differentiating the histomorphologic types of small renal parenchymal neoplasms. Materials and Methods: Double-phase helical CT (5 mm slice) of the cortico-medullary phase (CMP) and late nephrographic phase (NP) was performed in 40 surgically resected renal neoplasms <3.5 cm. The patterns of CT attenuation value and homogeneity were correlated with the subtypes of neoplasms, microvessel density, and the existence of intratumoral necrosis or hemorrhage. Results: Clear cell renal cell carcinomas (RCC) (n = 29) showed a peak attenuation value in the CMP of >100 HU [Hounsfield units]. Chromophobe cell RCC (n = 2) showed a peak attenuation value in the CMP of <100 HU. Papillary RCC (n = 5) showed a gradual enhancement with the attenuation value in the CMP of <100 HU. However oncocytomas (n = 2) and metanephric adenomas (n = 2) also showed patterns similar to these subtypes of RCC. The degree of enhancement in the CMP correlated with microvessel density (r = 0.87). All tumors with an homogeneous enhancement pattern did not show necrosis or hemorrhage on histologic specimen. Conclusion: The enhancement pattern in double-phase helical CT was different among the subtypes of RCC, and correlated with microvessel density or the existence of intratumoral necrosis or hemorrhage. However it did not differentiate between RCC and other solid tumors.

KW - Computed tomography, helical

KW - Kidneys, abnormalities

KW - Kidneys, neoplasms

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