TY - GEN
T1 - Droplet-box
T2 - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
AU - Yasuga, H.
AU - Kawano, R.
AU - Takinoue, M.
AU - Tsuji, Y.
AU - Osaki, T.
AU - Kamiya, K.
AU - Miki, N.
AU - Takeuchi, S.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - This paper proposes a system of biological-nanopore-based logic gates using a lipid-coated droplet network that is set up mechanically. The droplet network can be allowed to behave as various logic gates by simply changing the arrangement. A box that has open windows in each lateral face contains an aqueous droplet with a lipid monolayer in organic solvent, which we term as Droplet-Box (DB). The DBs can be manually handled and when they are contacted, a Droplet Interface Bilayer (DIB) is formed at the interface. In this study, we consider the DBs as electronic parts and construct logic gates using the DB network, where an a-Hemolysin (aHL) channel current corresponds to switch-ON. We successfully demonstrated AND, OR, and NOT using the DB network.
AB - This paper proposes a system of biological-nanopore-based logic gates using a lipid-coated droplet network that is set up mechanically. The droplet network can be allowed to behave as various logic gates by simply changing the arrangement. A box that has open windows in each lateral face contains an aqueous droplet with a lipid monolayer in organic solvent, which we term as Droplet-Box (DB). The DBs can be manually handled and when they are contacted, a Droplet Interface Bilayer (DIB) is formed at the interface. In this study, we consider the DBs as electronic parts and construct logic gates using the DB network, where an a-Hemolysin (aHL) channel current corresponds to switch-ON. We successfully demonstrated AND, OR, and NOT using the DB network.
KW - Biological nanopore
KW - Droplet Interface Bilayer
KW - Droplet contact method
KW - Lipid bilayer
KW - Logic gate
KW - Membrane protein
UR - http://www.scopus.com/inward/record.url?scp=84907354227&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907354227&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84907354227
SN - 9781632666246
T3 - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
SP - 1914
EP - 1916
BT - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PB - Chemical and Biological Microsystems Society
Y2 - 27 October 2013 through 31 October 2013
ER -