Droplet-box: A platform for biological-nanopore-based logical operation using lipid-coated droplet network

H. Yasuga, R. Kawano, M. Takinoue, Y. Tsuji, T. Osaki, K. Kamiya, N. Miki, S. Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

This paper proposes a system of biological-nanopore-based logic gates using a lipid-coated droplet network that is set up mechanically. The droplet network can be allowed to behave as various logic gates by simply changing the arrangement. A box that has open windows in each lateral face contains an aqueous droplet with a lipid monolayer in organic solvent, which we term as Droplet-Box (DB). The DBs can be manually handled and when they are contacted, a Droplet Interface Bilayer (DIB) is formed at the interface. In this study, we consider the DBs as electronic parts and construct logic gates using the DB network, where an a-Hemolysin (aHL) channel current corresponds to switch-ON. We successfully demonstrated AND, OR, and NOT using the DB network.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages1914-1916
Number of pages3
ISBN (Print)9781632666246
Publication statusPublished - 2013 Jan 1
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 2013 Oct 272013 Oct 31

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume3

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period13/10/2713/10/31

Keywords

  • Biological nanopore
  • Droplet Interface Bilayer
  • Droplet contact method
  • Lipid bilayer
  • Logic gate
  • Membrane protein

ASJC Scopus subject areas

  • Bioengineering

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  • Cite this

    Yasuga, H., Kawano, R., Takinoue, M., Tsuji, Y., Osaki, T., Kamiya, K., Miki, N., & Takeuchi, S. (2013). Droplet-box: A platform for biological-nanopore-based logical operation using lipid-coated droplet network. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 (pp. 1914-1916). (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Vol. 3). Chemical and Biological Microsystems Society.