TY - JOUR
T1 - Drug attitude, insight, and patient’s knowledge about prescribed antipsychotics in schizophrenia
T2 - A cross-sectional survey
AU - Nagai, Nobuhiro
AU - Tani, Hideaki
AU - Yoshida, Kazunari
AU - Gerretsen, Philip
AU - Suzuki, Takefumi
AU - Ikai-Tani, Saeko
AU - Mimura, Masaru
AU - Uchida, Hiroyuki
N1 - Funding Information:
This research was funded by the Inokashira Hospital Grant for Psychiatry Research.
Funding Information:
Dr Nagai has received personal/manuscript fees from Sumitomo Dainippon Pharma within the past 3 years. Dr Tani has received grants from Eli Lilly and the Japanese Society of Clinical Neuropsychopharmacology; manuscript or personal/speaker’s fees from Otsuka, Sumitomo Dainippon Pharma, Wiley, and Yoshitomi Yakuhin, outside the submitted work. Dr Yoshida has received manuscript/personal fees from Sumitomo Dainippon Pharma, fellowship grants from the Japan Research Foundation for Clinical Pharmacology, Azrieli Centre Postdoctoral Fellowship at CAMH, and personal/ consultant fees from Signant Health and VeraSci within the past 3 years. Dr Gerretsen has received research supports/ grants from the Canadian Institutes of Health Research (CIHR), Ontario Mental Health Foundation, and Centre for Addiction and Mental Health Foundation. He has also received Academic Scholar Award from the Department of Psychiatry, University of Toronto, grants from Alternative Funding Program Innovation Fund, Ministry of Health and Long-term Care, outside the submitted work; In addition, Dr Gerretsen reports a patent VAGUS Scale. Dr Suzuki has received manuscript or personal/speaker’s fees from Astellas, Dainippon Sumitomo Pharma, Eisai, Eli Lilly, Elsevier Japan, Janssen Pharmaceuticals, Kyowas Yakuhin, Meiji Seika Pharma, Mitsubishi Tanabe Pharma, MSD, Novartis, Otsuka Pharmaceutical, Shionogi Tsumura, Wiley Japan, and Yoshitomi Yakuhin within the past 3 years; grants from Eisai, Mochida Pharmaceutical, and Meiji Seika Pharma, outside the submitted work. Dr Ikai-Tani has received a manuscript/personal fees from Sumitomo Dainippon Pharma for the past 3 years. Dr Uchida has received grants and/or personal fees from Astellas Pharmaceutical, Eisai, Otsuka Pharmaceutical, Shionogi, Dainippon-Sumitomo Pharma, Eli Lilly, Mochida Pharmaceutical, Meiji-Seika Pharmaceutical, and Novartis; speaker’s honoraria from Otsuka Pharmaceutical, Eli Lilly, Shionogi, Pfizer, Yoshitomi Yakuhin, Dainippon-Sumitomo Pharma, Meiji-Seika Pharma, MSD, and Janssen Pharmaceutical; and advisory panel payments from Dainippon-Sumitomo Pharma within the past 3 years. Dr Mimura has received speaker’s honoraria and/or grants/personal fees from Daiichi Sankyo, Dainippon-Sumitomo Pharma, Eisai, Eli Lilly, Fuji Film RI Pharma, Janssen Pharmaceutical, Mochida Pharmaceutical, MSD, Nippon Chemipher, Novartis Pharma, Ono Yakuhin, Otsuka Pharmaceutical, Pfizer, Shionogi, Takeda Yakuhin, Tanabe Mitsubishi, Tsumura, and Yoshitomi Yakuhin within the past 3 years. The authors report no other conflicts of interest in this work.
Publisher Copyright:
© 2020 Nagai et al.
PY - 2020
Y1 - 2020
N2 - Introduction: While patients’ perspectives toward pharmacotherapy are expected to be directly influenced by their motivation and understanding of the treatment that they are currently receiving, no study has comprehensively investigated the impact of insight into illness and knowledge for the ongoing pharmacotherapy on the attitude towards drug treatment among patients with schizophrenia. Materials and Methods: One hundred forty-eight Japanese outpatients diagnosed with schizophrenia, according to the International Classification of Diseases 10th edition, were included (mean±SD age, 47.3±12.4 years; 90 men (60.8%)). Attitudes toward antipsychotic treatment and insight into illness were assessed with the Drug Attitude Inventory-10 (DAI-10) and the VAGUS, respectively. In addition, a multiple-choice questionnaire that was designed to examine patients’ knowledge about therapeutic effects, types, and implicated neurotransmitters of antipsychotic drugs they were receiving was utilized. Results: The mean±SD of DAI-10 score was 4.7±4.2. The multiple regression analysis found that lower Positive and Negative Syndrome Scale (PANSS) scores, higher VAGUS scores, and longer illness duration were significantly associated with higher DAI-10 scores (β=−0.226, P=0.009; β=0.250, P=0.008; β=0.203, P=0.034, respectively). There was a significant difference in the DAI-10 scores between the subjects who gave more accurate answers regarding the effects of their primary antipsychotic and those who did not (mean ±SD, 5.57±4.38 vs 4.13±4.04, P=0.043); however, this finding failed to survive the multiple regression analysis. Conclusion: Better insight into illness and treatment, lower illness severity, longer illness duration, and possibly greater knowledge about the therapeutic effects of medications may lead to better attitudes towards pharmacotherapy among patients with schizophrenia, which has an important implication for this typically chronic mental condition requiring long-term antipsychotic treatment to sustain stability.
AB - Introduction: While patients’ perspectives toward pharmacotherapy are expected to be directly influenced by their motivation and understanding of the treatment that they are currently receiving, no study has comprehensively investigated the impact of insight into illness and knowledge for the ongoing pharmacotherapy on the attitude towards drug treatment among patients with schizophrenia. Materials and Methods: One hundred forty-eight Japanese outpatients diagnosed with schizophrenia, according to the International Classification of Diseases 10th edition, were included (mean±SD age, 47.3±12.4 years; 90 men (60.8%)). Attitudes toward antipsychotic treatment and insight into illness were assessed with the Drug Attitude Inventory-10 (DAI-10) and the VAGUS, respectively. In addition, a multiple-choice questionnaire that was designed to examine patients’ knowledge about therapeutic effects, types, and implicated neurotransmitters of antipsychotic drugs they were receiving was utilized. Results: The mean±SD of DAI-10 score was 4.7±4.2. The multiple regression analysis found that lower Positive and Negative Syndrome Scale (PANSS) scores, higher VAGUS scores, and longer illness duration were significantly associated with higher DAI-10 scores (β=−0.226, P=0.009; β=0.250, P=0.008; β=0.203, P=0.034, respectively). There was a significant difference in the DAI-10 scores between the subjects who gave more accurate answers regarding the effects of their primary antipsychotic and those who did not (mean ±SD, 5.57±4.38 vs 4.13±4.04, P=0.043); however, this finding failed to survive the multiple regression analysis. Conclusion: Better insight into illness and treatment, lower illness severity, longer illness duration, and possibly greater knowledge about the therapeutic effects of medications may lead to better attitudes towards pharmacotherapy among patients with schizophrenia, which has an important implication for this typically chronic mental condition requiring long-term antipsychotic treatment to sustain stability.
KW - Adherence
KW - Antipsychotic
KW - Drug attitude
KW - Insight
KW - Knowledge
KW - Schizophrenia
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U2 - 10.2147/NDT.S240377
DO - 10.2147/NDT.S240377
M3 - Article
AN - SCOPUS:85082808678
SN - 1176-6328
VL - 16
SP - 781
EP - 787
JO - Neuropsychiatric Disease and Treatment
JF - Neuropsychiatric Disease and Treatment
ER -
