Drug-carrying latices for prolonged release of drugs

H. Kawaguchi, S. Kataiwa, T. Mita, Y. Ohtsuka, T. Takeuchi, S. Kobayashi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Dichlorophene was used as a model drug. Drug-carrying latex particles were prepared by soap-free emulsion copolymerization of dichlorophene acrylate with some hydrophilic methacrylate comonomers. The comonomers used affected not only the structure and colloidal stability of particles, but also the drug-activity of particles. Preliminary study of the drug activity revealed that highly hydrophilic latex particles were very stable and too inactive to be engulfed by amoebae and kill them. On the contrary, less hydrophilic particles carrying a large amount of drug can be an effective device to release drugs at a moderate rate to fight against extracelluar targets such as parasites.

Original languageEnglish
Pages (from-to)1167-1173
Number of pages7
JournalColloid & Polymer Science
Volume268
Issue number12
DOIs
Publication statusPublished - 1990 Dec 1

Keywords

  • Dichlorophene
  • latex particles
  • polymer drug
  • prolonged drug-release
  • soap-free emulsion polymerization

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Colloid and Surface Chemistry
  • Materials Chemistry

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  • Cite this

    Kawaguchi, H., Kataiwa, S., Mita, T., Ohtsuka, Y., Takeuchi, T., & Kobayashi, S. (1990). Drug-carrying latices for prolonged release of drugs. Colloid & Polymer Science, 268(12), 1167-1173. https://doi.org/10.1007/BF01410683