Drug discovery assisted by kinetic target guided synthesis

Research output: Contribution to journalArticle

Abstract

One of the modern medicinal chemistry methods is kinetic target-guided synthesis, where fragment molecules are interacted with a target protein and those in close proximity on the protein spontaneously cross - link by forming a covalent bond. The reactions, which is applicable to the kinetic target-guided synthesis proceed in water and are required no additional reagent. Here, several examples of kinetic target - guided synthesis are described.

Original languageEnglish
Pages (from-to)1245-1246
Number of pages2
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume73
Issue number12
Publication statusPublished - 2015
Externally publishedYes

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Kinetics
Covalent bonds
Proteins
Molecules
Water
Drug Discovery
Pharmaceutical Chemistry

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Drug discovery assisted by kinetic target guided synthesis. / Matsumaru, Takanori.

In: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, Vol. 73, No. 12, 2015, p. 1245-1246.

Research output: Contribution to journalArticle

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