Drugs targeting intracellular molecule: JAK inhibitor and syk inhibitor

Kunihiro Yamaoka, Kazuyoshi Saito, Yoshiya Tanaka

Research output: Contribution to journalReview articlepeer-review


Biologies targeting TNF-a and IL-6 have dramatically changed the treatment of rheumatoid arthritis (RA). Previously the therapeutic aim was to control the symptoms of arthritis. However, today our treatment goal is to achieve remission. Inflammatory cytokines involved in the pathology of RA activate multiple signaling pathways in the cytoplasm. Hence, regulating these intracellular signaling pathways has been expected to achieve similar treatment effects as biologies on RA. Recent clinical trials with compounds targeting Janus kinase (JAK) or spleen tyrosine kinase (Syk) have demonstrated high clinical efficacy resembling the biologies. Here we overview the development process of these inhibitors together with the results of clinical trials.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalJapanese Journal of Clinical Pharmacology and Therapeutics
Issue number1
Publication statusPublished - 2013 Jan 1


  • JAK
  • Rheumatoid arthritis
  • Syk

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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