Dynamic cooperation between epidermal barriers and Langerhans cells

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Skin is the structure that covers our body and protects it from not only the entry of pathogens or allergens but also from the leakage of water, solutes or nutrients. These outside-in and inside-out skin barrier functions are dependent on the epidermis, a stratified epithelial cellular sheet.While mucus covers the epidermis in fish and amphibian tadpoles, ter- minally differentiated cornified cellular sheets called stratum corneum (SC) constitute the outermost epidermal barrier in amphibian adults, reptiles, birds and mammals. Beneath the mucus or SC, apical paracellular spaces of epidermal cells are sealed with tight junctions (TJs) that might limit paracellular leakage of water and electrolytes to maintain fluid homeostasis. We have recently reported in mice that Langerhans cells (LCs) elongate their dendrites to penetrate through epidermal TJs upon activation and uptake antigens from extra-TJ environment. During antigen uptake, new TJs are formed between keratinocytes and LC dendrites to maintain the integrity of epidermal TJ barriers. To under- stand the epidermal barrier system and its deficiency observed in human skin diseases, we need to re-evaluate human epidermal barrier as a composite barrier consisting of SC and TJs and to investigate the molecular mechanism and im- munological consequences of the extra-TJ antigen uptake activity of LCs.

Original languageEnglish
Pages (from-to)76-84
Number of pages9
JournalJapanese Journal of Clinical Immunology
Volume34
Issue number2
DOIs
Publication statusPublished - 2011

Fingerprint

Langerhans Cells
Tight Junctions
Cornea
Amphibians
Mucus
Dendrites
Antigens
Epidermis
Skin
Reptiles
Water
Keratinocytes
Skin Diseases
Allergens
Electrolytes
Birds
Larva
Mammals
Fishes
Homeostasis

Keywords

  • Atopic dermatitis
  • Langerhans cell
  • Skin barrier
  • Stratum corneum
  • Tight junction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Dynamic cooperation between epidermal barriers and Langerhans cells. / Kubo, Akiharu.

In: Japanese Journal of Clinical Immunology, Vol. 34, No. 2, 2011, p. 76-84.

Research output: Contribution to journalArticle

@article{ebff85db580f47bf880c941012612258,
title = "Dynamic cooperation between epidermal barriers and Langerhans cells",
abstract = "Skin is the structure that covers our body and protects it from not only the entry of pathogens or allergens but also from the leakage of water, solutes or nutrients. These outside-in and inside-out skin barrier functions are dependent on the epidermis, a stratified epithelial cellular sheet.While mucus covers the epidermis in fish and amphibian tadpoles, ter- minally differentiated cornified cellular sheets called stratum corneum (SC) constitute the outermost epidermal barrier in amphibian adults, reptiles, birds and mammals. Beneath the mucus or SC, apical paracellular spaces of epidermal cells are sealed with tight junctions (TJs) that might limit paracellular leakage of water and electrolytes to maintain fluid homeostasis. We have recently reported in mice that Langerhans cells (LCs) elongate their dendrites to penetrate through epidermal TJs upon activation and uptake antigens from extra-TJ environment. During antigen uptake, new TJs are formed between keratinocytes and LC dendrites to maintain the integrity of epidermal TJ barriers. To under- stand the epidermal barrier system and its deficiency observed in human skin diseases, we need to re-evaluate human epidermal barrier as a composite barrier consisting of SC and TJs and to investigate the molecular mechanism and im- munological consequences of the extra-TJ antigen uptake activity of LCs.",
keywords = "Atopic dermatitis, Langerhans cell, Skin barrier, Stratum corneum, Tight junction",
author = "Akiharu Kubo",
year = "2011",
doi = "10.2177/jsci.34.76",
language = "English",
volume = "34",
pages = "76--84",
journal = "Immunological Medicine",
issn = "0911-4300",
publisher = "Taylor and Francis Ltd.",
number = "2",

}

TY - JOUR

T1 - Dynamic cooperation between epidermal barriers and Langerhans cells

AU - Kubo, Akiharu

PY - 2011

Y1 - 2011

N2 - Skin is the structure that covers our body and protects it from not only the entry of pathogens or allergens but also from the leakage of water, solutes or nutrients. These outside-in and inside-out skin barrier functions are dependent on the epidermis, a stratified epithelial cellular sheet.While mucus covers the epidermis in fish and amphibian tadpoles, ter- minally differentiated cornified cellular sheets called stratum corneum (SC) constitute the outermost epidermal barrier in amphibian adults, reptiles, birds and mammals. Beneath the mucus or SC, apical paracellular spaces of epidermal cells are sealed with tight junctions (TJs) that might limit paracellular leakage of water and electrolytes to maintain fluid homeostasis. We have recently reported in mice that Langerhans cells (LCs) elongate their dendrites to penetrate through epidermal TJs upon activation and uptake antigens from extra-TJ environment. During antigen uptake, new TJs are formed between keratinocytes and LC dendrites to maintain the integrity of epidermal TJ barriers. To under- stand the epidermal barrier system and its deficiency observed in human skin diseases, we need to re-evaluate human epidermal barrier as a composite barrier consisting of SC and TJs and to investigate the molecular mechanism and im- munological consequences of the extra-TJ antigen uptake activity of LCs.

AB - Skin is the structure that covers our body and protects it from not only the entry of pathogens or allergens but also from the leakage of water, solutes or nutrients. These outside-in and inside-out skin barrier functions are dependent on the epidermis, a stratified epithelial cellular sheet.While mucus covers the epidermis in fish and amphibian tadpoles, ter- minally differentiated cornified cellular sheets called stratum corneum (SC) constitute the outermost epidermal barrier in amphibian adults, reptiles, birds and mammals. Beneath the mucus or SC, apical paracellular spaces of epidermal cells are sealed with tight junctions (TJs) that might limit paracellular leakage of water and electrolytes to maintain fluid homeostasis. We have recently reported in mice that Langerhans cells (LCs) elongate their dendrites to penetrate through epidermal TJs upon activation and uptake antigens from extra-TJ environment. During antigen uptake, new TJs are formed between keratinocytes and LC dendrites to maintain the integrity of epidermal TJ barriers. To under- stand the epidermal barrier system and its deficiency observed in human skin diseases, we need to re-evaluate human epidermal barrier as a composite barrier consisting of SC and TJs and to investigate the molecular mechanism and im- munological consequences of the extra-TJ antigen uptake activity of LCs.

KW - Atopic dermatitis

KW - Langerhans cell

KW - Skin barrier

KW - Stratum corneum

KW - Tight junction

UR - http://www.scopus.com/inward/record.url?scp=79957969226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957969226&partnerID=8YFLogxK

U2 - 10.2177/jsci.34.76

DO - 10.2177/jsci.34.76

M3 - Article

C2 - 21628849

AN - SCOPUS:79957969226

VL - 34

SP - 76

EP - 84

JO - Immunological Medicine

JF - Immunological Medicine

SN - 0911-4300

IS - 2

ER -